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8-Azaadenine

Name: 8-Azaadenine
Brand: TargetMol
SKU: T20042
Price: 21 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20042Cas No. 1123-54-2

Alias NSC-32797, NSC32797, NSC 32797

8-Azaadenine (NSC-32797) is an inhibitor of xanthine oxidase with IC50 of 0.54 μM and Ki of 0.66 μM.

8-Azaadenine

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Purity: 99.68%

Catalog No. T20042Alias NSC-32797, NSC32797, NSC 32797Cas No. 1123-54-2

8-Azaadenine (NSC-32797) is an inhibitor of xanthine oxidase with IC50 of 0.54 μM and Ki of 0.66 μM.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$30	-	In Stock
1 mL x 10 mM (in DMSO)	$21	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.68%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

8-Azaadenine AI Summary

8-Azaadenine exhibits cytotoxicity against African green monkey Vero cells, with a median toxic dose (MTD) of 18.7 µM after 24 hours of incubation, as demonstrated by the neutral red uptake assay. Additionally, this compound shows bioactivity as an inhibitor of ATPgammaS-BODIPY binding to Thermotoga maritima His-tagged HK853 expressed in Escherichia coli, with an IC50 value of 13.66 µM, indicating its effectiveness in inhibiting this specific molecular interaction..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	8-Azaadenine (NSC-32797) is an inhibitor of xanthine oxidase with IC50 of 0.54 μM and Ki of 0.66 μM.
Synonyms	NSC-32797, NSC32797, NSC 32797

Chemical Properties

Molecular Weight	136.11
Formula	C₄H₄N₆
Cas No.	1123-54-2
Smiles	NC1=NC=NC2=NNN=C12
Relative Density.	2.26g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (73.47 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (7.35 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.3470 mL	36.7350 mL	73.4700 mL	367.3499 mL
5 mM	1.4694 mL	7.3470 mL	14.6940 mL	73.4700 mL
10 mM	0.7347 mL	3.6735 mL	7.3470 mL	36.7350 mL
20 mM	0.3673 mL	1.8367 mL	3.6735 mL	18.3675 mL
50 mM	0.1469 mL	0.7347 mL	1.4694 mL	7.3470 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc