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Herboxidiene

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Catalog No. T36749Cas No. 142861-00-5
Alias GEX1A

Herboxidiene (GEX1A) is a plant-toxic polyketide compound isolated from Streptomyces ATCC 49982, with herbicidal, cholesterol-lowering, and anticancer activities. It exhibits anti-angiogenic activity by downregulating vascular endothelial growth factor receptor-2 (VEGFR-2) and hypoxia-inducible factor-1α (HIF-1α).

Herboxidiene

Herboxidiene

😃Good
Catalog No. T36749Alias GEX1ACas No. 142861-00-5
Herboxidiene (GEX1A) is a plant-toxic polyketide compound isolated from Streptomyces ATCC 49982, with herbicidal, cholesterol-lowering, and anticancer activities. It exhibits anti-angiogenic activity by downregulating vascular endothelial growth factor receptor-2 (VEGFR-2) and hypoxia-inducible factor-1α (HIF-1α).
Pack SizePriceAvailabilityQuantity
500 μg$74035 days
1 mg$1,10035 days
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Product Introduction

Bioactivity
Description
Herboxidiene (GEX1A) is a plant-toxic polyketide compound isolated from Streptomyces ATCC 49982, with herbicidal, cholesterol-lowering, and anticancer activities. It exhibits anti-angiogenic activity by downregulating vascular endothelial growth factor receptor-2 (VEGFR-2) and hypoxia-inducible factor-1α (HIF-1α).
In vivo
Methods: Herboxidiene (1 mg/kg, intraperitoneal injection) was administered to mice bearing SVT2 mouse fibrosarcoma model, and the changes of tumors in vivo were observed.
Results: Herboxidiene showed significant antitumor activity on day 4.[1]
SynonymsGEX1A
Chemical Properties
Molecular Weight438.6
FormulaC25H42O6
Cas No.142861-00-5
Smiles[C@H]([C@H]([C@@H](C)O)OC)(C)[C@@]1([C@](C[C@@H](/C=C/C=C(\C)/[C@H]2O[C@@H](CC(O)=O)CC[C@@H]2C)C)(C)O1)[H]
Relative Density.1.056 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: 1.00 mg/mL (2.28 mM), Sonication is recommended.
Dichloromethane: 1.00 mg/mL (2.28 mM), Sonication is recommended.
DMSO: 1.00 mg/mL (2.28 mM), Sonication is recommended.
Methanol: 1.00 mg/mL (2.28 mM), Sonication is recommended.
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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

Herboxidiene
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