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(E)-3,4-Dimethoxycinnamic acid
🥰Excellent
Catalog No. T37882Cas No. 14737-89-4
Alias (E)-O-Methylferulic acid
(E)-3,4-Dimethoxycinnamic acid is a less active isomer of 3,4-dimethoxycinnamic acid, a natural monomer from Securidaca inappendiculata Hassk. It exerts anti-apoptotic effects in L-02 cells via ROS-mediated signaling, showing potential in research related to inflammation and immunology.
(E)-3,4-Dimethoxycinnamic acid
🥰Excellent
Purity: 99.98%
Catalog No. T37882Alias (E)-O-Methylferulic acidCas No. 14737-89-4
(E)-3,4-Dimethoxycinnamic acid is a less active isomer of 3,4-dimethoxycinnamic acid, a natural monomer from Securidaca inappendiculata Hassk. It exerts anti-apoptotic effects in L-02 cells via ROS-mediated signaling, showing potential in research related to inflammation and immunology.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 500 mg | $42 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.98%
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Product Introduction
Bioactivity
Chemical Properties
| Description | (E)-3,4-Dimethoxycinnamic acid is a less active isomer of 3,4-dimethoxycinnamic acid, a natural monomer from Securidaca inappendiculata Hassk. It exerts anti-apoptotic effects in L-02 cells via ROS-mediated signaling, showing potential in research related to inflammation and immunology. |
| In vitro | (E)-3,4-Dimethoxycinnamic acid (25, 50, and 100 μM) alleviates ethanol exposure-induced apoptosis in L-02 cells [1]. (E)-3,4-Dimethoxycinnamic acid (25, 50, and 100 μM) inhibits the expression levels of Nox4 and p22phox in L-02 cells [1]. (E)-3,4-Dimethoxycinnamic acid (25, 50, and 100 μM) attenuates ethanol-induced MAPK phosphorylation in L-02 cells [1]. (E)-3,4-Dimethoxycinnamic acid reduces the expression levels of superoxide dismutase, catalase, and phospholipid hydroperoxide glutathione peroxidase in a dose- and time-dependent manner, while downregulating the Bax/Bcl-2 ratio and cleaved caspase-3 levels [1]. |
| Synonyms | (E)-O-Methylferulic acid |
| Molecular Weight | 208.21 |
| Formula | C11H12O4 |
| Cas No. | 14737-89-4 |
| Smiles | O(C)C1=C(OC)C=CC(/C=C/C(O)=O)=C1 |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | keep away from direct sunlight,store under nitrogen,The compound is unstable in solution. Please use soon | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (192.11 mM), Sonication is recommeded. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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