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KS106

Name: KS106
Brand: TargetMol
SKU: T63081
Rating: 4.5 (1 reviews)

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Catalog No. T63081Cas No. 2408477-50-7

KS106 is a selective and potent ALDH inhibitor with antiproliferative and anticancer activity, inhibits ALDH1A1, ALDH2, and ALDH3A1 with IC50 of 334, 2137, and 360 nM, respectively.KS106 contributes to apoptosis, induces an increase in G2/M cell cycle arrest, and can be used to study melanoma and colon cancer.

KS106

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Purity: 99.31%

Catalog No. T63081Cas No. 2408477-50-7

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$916	6-8 weeks	6-8 weeks
50 mg	$1,190	6-8 weeks	6-8 weeks
100 mg	$1,810	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.31%

Appearance:Solid

Color:Yellow

Resource Download

COA CNMR HPLC MS HNMR

Product Introduction

Bioactivity

Description	KS106 is a selective and potent ALDH inhibitor with antiproliferative and anticancer activity, inhibits ALDH1A1, ALDH2, and ALDH3A1 with IC50 of 334, 2137, and 360 nM, respectively.KS106 contributes to apoptosis, induces an increase in G2/M cell cycle arrest, and can be used to study melanoma and colon cancer.
Targets&IC50	ALDH2:2137 nM, ALDH3A1:360 nM, ALDH1A1:334 nM
In vitro	In HCT116 and HT29 cells, KS106 (5 µM; 24 hours) induces cell apoptosis[1].

Chemical Properties

Molecular Weight	474.3
Formula	C₁₈H₁₅BrF₃N₃O₂S
Cas No.	2408477-50-7
Smiles	Br.NC(=N)SCc1ccc(CN2C(=O)C(=O)c3cc(ccc23)C(F)(F)F)cc1

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (168.67 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1084 mL	10.5419 mL	21.0837 mL	105.4185 mL
5 mM	0.4217 mL	2.1084 mL	4.2167 mL	21.0837 mL
10 mM	0.2108 mL	1.0542 mL	2.1084 mL	10.5419 mL
20 mM	0.1054 mL	0.5271 mL	1.0542 mL	5.2709 mL
50 mM	0.0422 mL	0.2108 mL	0.4217 mL	2.1084 mL
100 mM	0.0211 mL	0.1054 mL	0.2108 mL	1.0542 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc