APGW-amide is a neuropeptide capable of controlling the growth of pseudomale structures and promoting body growth in Haliotis asinina. It inhibits the Achatina neuron type, regulating currents induced by neuroactive compounds in neurons. APGW-amide induces a rapid increase in [Ca2+]i in Fura-2/AM-loaded PC12 cells and is useful for studies of the nervous system.

APGW-amide (3 μM) enhances the membrane conductance (g) value measured prior to I out induced by erythro-l-BHGA, with an ED50 of 76.9 ms, slope of 0.89274, Hill coefficient of 1.59453, and E max of 5.54 nA. It also inhibits the I out caused by Dopamine, showing an ED50 of 29.5 ms, slope of 1.02386, Hill coefficient of 1.9761, and E max of 0.38 nA, while increasing the pre-measured g value for Dopamine-induced I out. Additionally, APGW-amide (3 μM) suppresses the rapid component of I in induced by Serotonin, with an ED50 of 18.5 ms, slope of 0.8268, Hill coefficient of 1.6557, and E max of 0.72 nA. Furthermore, APGW-amide (30 μM) causes a rapid increase in [Ca 2+ ] i in Fura-2/AM-loaded PC12 cells.

APGW-amide, administered weekly at 20-200 ng/g for 14 weeks, enhances somatic growth in Haliotis asinina. Additionally, when given every other day for 14 days at concentrations of 0.0000001-0.01 nM, APGW-amide can induce imposex in the mud snail Ilyanassa obsoleta.