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APGW-amide
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Catalog No. TP3836Cas No. 126675-52-3
APGW-amide is a neuropeptide capable of controlling the growth of pseudomale structures and promoting body growth in Haliotis asinina. It inhibits the Achatina neuron type, regulating currents induced by neuroactive compounds in neurons. APGW-amide induces a rapid increase in [Ca2+]i in Fura-2/AM-loaded PC12 cells and is useful for studies of the nervous system.
APGW-amide
Copy Product Info😃Good
Catalog No. TP3836Cas No. 126675-52-3
APGW-amide is a neuropeptide capable of controlling the growth of pseudomale structures and promoting body growth in Haliotis asinina. It inhibits the Achatina neuron type, regulating currents induced by neuroactive compounds in neurons. APGW-amide induces a rapid increase in [Ca2+]i in Fura-2/AM-loaded PC12 cells and is useful for studies of the nervous system.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | APGW-amide is a neuropeptide capable of controlling the growth of pseudomale structures and promoting body growth in Haliotis asinina. It inhibits the Achatina neuron type, regulating currents induced by neuroactive compounds in neurons. APGW-amide induces a rapid increase in [Ca2+]i in Fura-2/AM-loaded PC12 cells and is useful for studies of the nervous system. |
| In vitro | APGW-amide (3 μM) enhances the membrane conductance (g) value measured prior to I out induced by erythro-l-BHGA, with an ED50 of 76.9 ms, slope of 0.89274, Hill coefficient of 1.59453, and E max of 5.54 nA. It also inhibits the I out caused by Dopamine, showing an ED50 of 29.5 ms, slope of 1.02386, Hill coefficient of 1.9761, and E max of 0.38 nA, while increasing the pre-measured g value for Dopamine-induced I out. Additionally, APGW-amide (3 μM) suppresses the rapid component of I in induced by Serotonin, with an ED50 of 18.5 ms, slope of 0.8268, Hill coefficient of 1.6557, and E max of 0.72 nA. Furthermore, APGW-amide (30 μM) causes a rapid increase in [Ca 2+ ] i in Fura-2/AM-loaded PC12 cells. |
| In vivo | APGW-amide, administered weekly at 20-200 ng/g for 14 weeks, enhances somatic growth in Haliotis asinina. Additionally, when given every other day for 14 days at concentrations of 0.0000001-0.01 nM, APGW-amide can induce imposex in the mud snail Ilyanassa obsoleta. |
| Molecular Weight | 428.49 |
| Formula | C21H28N6O4 |
| Cas No. | 126675-52-3 |
| Smiles | C([C@H](NC(CNC(=O)[C@H]1N(C([C@H](C)N)=O)CCC1)=O)C(N)=O)C=2C=3C(NC2)=CC=CC3 |
| Sequence | Ala-Pro-Gly-Trp-NH2 |
| Sequence Short | APGW |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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