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Espindolol

Name: Espindolol
Brand: TargetMol
SKU: T27285
Rating: 4.5 (1 reviews)

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Catalog No. T27285Cas No. 26328-11-0

Alias MT-102, MT102, MT 102, AGI-001, AGI001, AGI 001

Espindolol is a novel non-selective β blocker with central 5-HT1a and partial β2 receptor agonist effects.

Espindolol

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Purity: 99.96%

Catalog No. T27285Alias MT-102, MT102, MT 102, AGI-001, AGI001, AGI 001Cas No. 26328-11-0

Espindolol is a novel non-selective β blocker with central 5-HT1a and partial β2 receptor agonist effects.

Pack Size	Price	Availability
1 mg	$63	6-8 weeks
5 mg	$149	6-8 weeks
10 mg	$197	6-8 weeks
25 mg	$352	6-8 weeks
50 mg	$529	6-8 weeks
100 mg	$797	6-8 weeks
1 mL x 10 mM (in DMSO)	$164	6-8 weeks

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.96%

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COA

Product Introduction

Bioactivity

Description	Espindolol is a novel non-selective β blocker with central 5-HT1a and partial β2 receptor agonist effects.
In vivo	Placebo-treated rats progressively lost body weight (-15.5 ± 7.2 g), lean mass (-1.5 ± 4.2 g), and fat mass (-15.6 ± 2.7 g), while espindolol treatment increased body weight (+8.0 ± 6.1 g, p < 0.05), particularly lean mass (+43.4 ± 3.5 g, p < 0.001), and reduced fat mass further (-38.6 ± 3.4 g, p < 0.001). Anabolic/catabolic signaling was assessed in gastrocnemius muscle. Espindolol decreased proteasome and caspase-3 proteolytic activities by approximately 50 % (all p < 0.05)[1].
Synonyms	MT-102, MT102, MT 102, AGI-001, AGI001, AGI 001

Chemical Properties

Molecular Weight	248.32
Formula	C₁₄H₂₀N₂O₂
Cas No.	26328-11-0
Smiles	CC(C)NC[C@H](O)COc1cccc2[nH]ccc12
Relative Density.	1.152g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (221.49 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0271 mL	20.1353 mL	40.2706 mL	201.3531 mL
5 mM	0.8054 mL	4.0271 mL	8.0541 mL	40.2706 mL
10 mM	0.4027 mL	2.0135 mL	4.0271 mL	20.1353 mL
20 mM	0.2014 mL	1.0068 mL	2.0135 mL	10.0677 mL
50 mM	0.0805 mL	0.4027 mL	0.8054 mL	4.0271 mL
100 mM	0.0403 mL	0.2014 mL	0.4027 mL	2.0135 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc