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Proadifen hydrochloride

Name: Proadifen hydrochloride
Brand: TargetMol
SKU: T1597
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1597Cas No. 62-68-0

Alias U-5446, SKF-525A, RP-5171

Proadifen hydrochloride (RP-5171) is an inhibitor of drug metabolism and cytochrome P-450 enzyme system activity.

Proadifen hydrochloride

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Purity: 99.98%

Catalog No. T1597Alias U-5446, SKF-525A, RP-5171Cas No. 62-68-0

Proadifen hydrochloride (RP-5171) is an inhibitor of drug metabolism and cytochrome P-450 enzyme system activity.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$33	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.98%

Color:White

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COA HNMR LCMS

Product Introduction

Proadifen hydrochloride AI Summary

Proadifen hydrochloride exhibits a broad spectrum of bioactivities. It demonstrates potent antispasmodic activity against isolated guinea pig ileum, with an IC50 value of 0.0000012 M, and a potency relative to adiphenine of 0.62. It inhibits several enzymatic activities, such as Aryl hydrocarbon hydroxylase and Aminopyrine N-demethylase, with IC50 values of 22000.0 nM and 8200.0 nM respectively in phenobarbitone-treated rats. Additionally, it shows antiplasmodial activity against various strains of Plasmodium falciparum with IC50 values ranging from 1584.89 nM to 7943.28 nM. The compound inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3 transfected CHO cells. Furthermore, it demonstrates cytotoxicity in a HepG2 cell line with an IC50 of 57000.0 nM, and inhibits mitochondrial permeability transition pore as well as several specific enzymes and proteins, including HSD17B4, JMJD2E, TGF-b, and USP1/UAF1. Additionally, Proadifen hydrochloride activates the human and rat pregnane X receptor (PXR), inducing CYP3A4 expression in human liver cells, and exhibits antiviral activity against SARS-CoV-2 with inhibitory effects on both 3CL-Pro protease and virus-induced cytotoxicity in various cell lines. Its multifunctional bioactivities make it a potential candidate for further pharmacological investigation..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Proadifen hydrochloride (RP-5171) is an inhibitor of drug metabolism and cytochrome P-450 enzyme system activity.
Targets&IC50	CYP:19μM
Synonyms	U-5446, SKF-525A, RP-5171

Chemical Properties

Molecular Weight	389.96
Formula	C₂₃H₃₂ClNO₂
Cas No.	62-68-0
Smiles	Cl.CCCC(C(=O)OCCN(CC)CC)(c1ccccc1)c1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (115.4 mM), Sonication is recommended.

H2O: 197.4 mM, Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.13 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.5644 mL	12.8218 mL	25.6437 mL	128.2183 mL
5 mM	0.5129 mL	2.5644 mL	5.1287 mL	25.6437 mL
10 mM	0.2564 mL	1.2822 mL	2.5644 mL	12.8218 mL
20 mM	0.1282 mL	0.6411 mL	1.2822 mL	6.4109 mL
50 mM	0.0513 mL	0.2564 mL	0.5129 mL	2.5644 mL
100 mM	0.0256 mL	0.1282 mL	0.2564 mL	1.2822 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc