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Lactoferrin

Name: Lactoferrin
Brand: TargetMol
SKU: T9790
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9790Cas No. 936541-36-5

Alias Lactoferrin (Bovine)

Lactoferrin is secreted by mammals and displays extensive biological effects including boosting the cold tolerance of a well-applied probiotic strain.

Lactoferrin

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Purity: 99.86%

Catalog No. T9790Alias Lactoferrin (Bovine)Cas No. 936541-36-5

Lactoferrin is secreted by mammals and displays extensive biological effects including boosting the cold tolerance of a well-applied probiotic strain.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$39	In Stock	In Stock
25 mg	$83	In Stock	In Stock
50 mg	$122	In Stock	In Stock
100 mg	$182	In Stock	In Stock
500 mg	$474	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.86%

Appearance:Solid

Resource Download

COA HPLC

Product Introduction

Lactoferrin AI Summary

Lactoferrin exhibits strong inhibitory activities against several receptors and transport mechanisms. It demonstrates a significant inhibition of the [Ca(2+)]-permeable GluR3 receptor at 79.7% and much lower activity against the [Ca(2+)]-impermeable Ionotropic glutamate receptor AMPA at 4.3%. It also inhibits the transport of [3H]spermidine into MDA-MB-231 (human breast cancer) cells with a Ki value of 190.0 nM, indicating potential anti-cancer properties through spermidine transport inhibition. Additionally, it is a potent inhibitor of GluA1, GluA3, and GluA4 receptor flop isoforms, with IC50 values of 40.0 nM, 30.0 nM, and significant inhibition rates of 88.0%, 96.0%, and 82.0% at 0.5 µM, respectively. However, it does not significantly inhibit GluA1A2 and GluA2A3 receptor flop isoforms. It also shows antagonist activity against rat GluK1, GluA1, and glutamate N1/2A receptors with IC50 values of 19.0 nM, 65.0 nM, and 1710.0 nM, respectively. In cell viability assays, Lactoferrin negatively impacts the growth rate of HEK293T and U2OS cells, with growth rates ranging from -0.96 to -1.0, but has variable effects on human fibroblast cells, with growth rates ranging from -1.0 to 0.85, suggesting a cell-specific bioactivity profile..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Lactoferrin is secreted by mammals and displays extensive biological effects including boosting the cold tolerance of a well-applied probiotic strain.
Synonyms	Lactoferrin (Bovine)

Chemical Properties

Molecular Weight	565.716
Formula	C₂₇H₄₇N₇O₆
Cas No.	936541-36-5
Smiles	NCCCNCCCCNCCC(=O)NCCCCCNC(=O)[C@H](CC(N)=O)NC(=O)Cc1ccc(O)cc1O
Relative Density.	1.195g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 128.75 mg/mL (227.59 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.7677 mL	8.8384 mL	17.6767 mL	88.3836 mL
5 mM	0.3535 mL	1.7677 mL	3.5353 mL	17.6767 mL
10 mM	0.1768 mL	0.8838 mL	1.7677 mL	8.8384 mL
20 mM	0.0884 mL	0.4419 mL	0.8838 mL	4.4192 mL
50 mM	0.0354 mL	0.1768 mL	0.3535 mL	1.7677 mL
100 mM	0.0177 mL	0.0884 mL	0.1768 mL	0.8838 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc