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Antibacterial agent 332
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Catalog No. T218741 Copy Product Info
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Antibacterialagent 332 is an inhibitor of Escherichia coli DsbA (EcDsbA). It reduces the swarming motility of E. coli without affecting bacterial growth and can be used in studies of bacterial infections (Escherichia coli).
Antibacterial agent 332
Cas No. 3106820-05-4
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Antibacterialagent 332 is an inhibitor of Escherichia coli DsbA (EcDsbA). It reduces the swarming motility of E. coli without affecting bacterial growth and can be used in studies of bacterial infections (Escherichia coli). |
| In vitro | Antibacterial agent 332 (compound 17), in concentrations ranging from 0 to 100 mM, binds to Escherichia coli DsbA with a kinetic SPR K D of 2.2 μM and a steady-state SPR K D of 2.8 μM. When used at 50 μM with an injection interval of 180 seconds, its interaction with Escherichia coli DsbA yields an ITC K D value of 1.5 μM based on a single-site binding model. This compound inhibits the oxidation of native peptide substrates mediated by Escherichia coli DsbA in peptide oxidation assays with an IC 50 of 30 μM. Additionally, during ASMS screening, Antibacterial agent 332 demonstrated high enrichment rates, indicating the formation of stable complexes with Escherichia coli DsbA at room temperature over one hour. |
| Molecular Weight | 511.47 |
| Formula | C26H23F2N3O6 |
| Cas No. | 3106820-05-4 |
| Smiles | C([C@H](NC(C#CC1=CC(NC(=O)C2=NOC(C)=C2)=CC=C1)=O)CO)C3=CC(F)=C(CC(OC)=O)C(F)=C3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Antibacterial agent 332 in vitro | Antibacterial agent 332 formula | Antibacterial agent 332 molecular weight
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