16α-Hydroxyestrone

Name: 16α-Hydroxyestrone
Brand: TargetMol
SKU: T36039
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: 16αOHE) Copy Product Info

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Synonyms: 16αOHE

Catalog No. T36039 Copy Product Info

Purity: 99.70%

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16α-Hydroxyestrone is an important metabolite of estradiol, with important application value in basic research of metabolic diseases. It acts as an inhibitor of Breast cancer cell line MDA-MB-175-VII.

Cas No. 566-76-7

Pack Size	Price	USA Stock	Global Stock
1 mg	$98	-	In Stock
5 mg	$297	-	In Stock
10 mg	$479	-	In Stock
25 mg	$959	-	In Stock
50 mg	$1,530	-	In Stock
1 mL x 10 mM (in DMSO)	$327	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.70%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	16α-Hydroxyestrone is an important metabolite of estradiol, with important application value in basic research of metabolic diseases. It acts as an inhibitor of Breast cancer cell line MDA-MB-175-VII.
In vitro	Methods: The contents of two active estrogen metabolites of 16α-Hydroxyestrone in the body were detected, and their correlation with bone mineral density was analyzed. Results: The upregulation of active 16α-Hydroxyestrone and E3 levels was positively correlated with increased bone mineral density [1].
Synonyms	16αOHE

Chemical Properties

Molecular Weight	286.37
Formula	C₁₈H₂₂O₃
Cas No.	566-76-7
Smiles	C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(O)=CC4)(CC1)[H])[H])(C[C@@H](O)C2=O)[H]
Relative Density.	1.249 g/cm3 (Predicted)

Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO: 200 mg/mL (698.4 mM), Sonication is recommended. DMF: 30 mg/mL (104.76 mM), Sonication is recommended. DMF:PBS (pH 7.2) (1:5): 0.15 mg/mL (0.52 mM), Sonication is recommended.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.