Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

VII-31

🥰Excellent
Catalog No. T62334Cas No. 2305757-96-2
Alias VII31

VII-31 is an activator of the NEDDylation pathway, capable of inducing apoptosis in MCF-7, PC-3, and MGC-803 cells.

VII-31

VII-31

🥰Excellent
Catalog No. T62334Alias VII31Cas No. 2305757-96-2
VII-31 is an activator of the NEDDylation pathway, capable of inducing apoptosis in MCF-7, PC-3, and MGC-803 cells.
Pack SizePriceAvailabilityQuantity
1 mg$153In Stock
Add to Cart
Add to Quotation
Bulk & Custom
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
View More

Batch Information

Select Batch
Contact us for more batch information

Resource Download

Product Introduction

Bioactivity
Description
VII-31 is an activator of the NEDDylation pathway, capable of inducing apoptosis in MCF-7, PC-3, and MGC-803 cells.
Targets&IC50
MCF-7 cells:0.10±0.006 μM, PC-3 cells:1.15±0.28μM, MGC803 cells:0.09±0.01 μM
In vitro
Methods: MGC803, MCF-7 and PC-3 cells were treated with VII-31 (0-200 μM, 48 hours), and cell viability was detected by MTT assay.
Results: VII-31 inhibited the cell viability of MGC803, MCF-7 and PC-3 cells, with IC50 values ​​of 0.09±0.01 μM, 0.10±0.006 and 1.15±0.28 μM, respectively. [1]
In vivo
Methods: VII-31 (10, 50, 150 mg/kg, subcutaneous injection, 28 days) was used to treat MGC803 cancer cells to establish a subcutaneous transplant tumor model of human gastric cancer. The tumor size was measured with a caliper to study its effect on tumors in mice.
Results: Within 28 days after the first treatment, the tumor volume of mice in the VII-31 treatment group was significantly smaller than that in the control group; the tumor weight of the 50 mg/kg VII-31 treatment group was about 36% lower than that in the control group, and the tumor weight of the 100 mg/kg VII-31 and 150 mg/kg VII-31 treatment groups was 42% and 46% lower than that in the control group, respectively. VII-31 was able to inhibit the progression of tumors in mice and had no obvious toxicity to mice. [1]
AliasVII31
Chemical Properties
Molecular Weight427.51
FormulaC23H25NO5S
Cas No.2305757-96-2
SmilesO=C(N(C1=CC(OC)=C(OC)C(OC)=C1)CC2=CC=C(OC)C=C2)CC=3SC=CC3
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 200 mg/mL (467.83 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3391 mL11.6956 mL23.3913 mL116.9563 mL
5 mM0.4678 mL2.3391 mL4.6783 mL23.3913 mL
10 mM0.2339 mL1.1696 mL2.3391 mL11.6956 mL
20 mM0.1170 mL0.5848 mL1.1696 mL5.8478 mL
50 mM0.0468 mL0.2339 mL0.4678 mL2.3391 mL
100 mM0.0234 mL0.1170 mL0.2339 mL1.1696 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Related Tags: buy VII-31 | purchase VII-31 | VII-31 cost | order VII-31 | VII-31 chemical structure | VII-31 in vivo | VII-31 in vitro | VII-31 formula | VII-31 molecular weight