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VII-31 is an activator of the NEDDylation pathway, capable of inducing apoptosis in MCF-7, PC-3, and MGC-803 cells.
Pack Size | Price | Availability | Quantity |
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1 mg | $153 | In Stock |
Description | VII-31 is an activator of the NEDDylation pathway, capable of inducing apoptosis in MCF-7, PC-3, and MGC-803 cells. |
Targets&IC50 | MCF-7 cells:0.10±0.006 μM, PC-3 cells:1.15±0.28μM, MGC803 cells:0.09±0.01 μM |
In vitro | Methods: MGC803, MCF-7 and PC-3 cells were treated with VII-31 (0-200 μM, 48 hours), and cell viability was detected by MTT assay. Results: VII-31 inhibited the cell viability of MGC803, MCF-7 and PC-3 cells, with IC50 values of 0.09±0.01 μM, 0.10±0.006 and 1.15±0.28 μM, respectively. [1] |
In vivo | Methods: VII-31 (10, 50, 150 mg/kg, subcutaneous injection, 28 days) was used to treat MGC803 cancer cells to establish a subcutaneous transplant tumor model of human gastric cancer. The tumor size was measured with a caliper to study its effect on tumors in mice. Results: Within 28 days after the first treatment, the tumor volume of mice in the VII-31 treatment group was significantly smaller than that in the control group; the tumor weight of the 50 mg/kg VII-31 treatment group was about 36% lower than that in the control group, and the tumor weight of the 100 mg/kg VII-31 and 150 mg/kg VII-31 treatment groups was 42% and 46% lower than that in the control group, respectively. VII-31 was able to inhibit the progression of tumors in mice and had no obvious toxicity to mice. [1] |
Alias | VII31 |
Molecular Weight | 427.51 |
Formula | C23H25NO5S |
Cas No. | 2305757-96-2 |
Smiles | O=C(N(C1=CC(OC)=C(OC)C(OC)=C1)CC2=CC=C(OC)C=C2)CC=3SC=CC3 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 200 mg/mL (467.83 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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