C-MPL Protein, Rat, Recombinant (hFc)

CD11, also known as c-MPL, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. It is expressed at a low level in a large number of cells of hematopoietic origin. C-MPL is homologous with members of the hematopoietic receptor superfamily. The presence of anti-sense oligodeoxynucleotides of C-Mpl inhibited megakaryocyte colony formation. Thrombopoietin is the ligand for C-Mpl. It was shown to be the major regulator of megakaryocytopoiesis and platelet formation. Defects in c-MPL are a cause of congenital amegakaryocytic thrombocytopenia which is a disease characterized by isolated thrombocytopenia and Megakaryocytopenia with no physical anomalies. Defects in c-MPL also cause thrombocythemia type 2 and myelofibrosis with myeloid metaplasia.

Pack Size	Availability	Price/USD
50 μg	In stock	$ 228.00
100 μg	5 days	$ 392.00
200 μg	5 days	$ 670.00
500 μg	5 days	$ 1,350.00

Pack Size

Availability

Price/USD

Quantity

50 μg

In stock

$ 228.00

100 μg

5 days

$ 392.00

200 μg

5 days

$ 670.00

500 μg

5 days

$ 1,350.00

Biological Information

Testing in progress

Description

Species	Rat
Expression System	HEK293
Tag	hFc
Accession Number	A0A1W2Q6N1
Synonyms	MPL proto-oncogene, thrombopoietin receptor, MPL
Construction	A DNA sequence encoding the rat MPL (XP_001072502.1) (Met1-Ala500) was expressed with the Fc region of human IgG1 at the C-terminus.
Protein Purity	> 95 % as determined by SDS-PAGE.
Molecular Weight	Approxiamtely 80.7 kDa

Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method.
Formulation	Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Reconstitution	A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Stability & Storage	Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background	CD11, also known as c-MPL, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. It is expressed at a low level in a large number of cells of hematopoietic origin. C-MPL is homologous with members of the hematopoietic receptor superfamily. The presence of anti-sense oligodeoxynucleotides of C-Mpl inhibited megakaryocyte colony formation. Thrombopoietin is the ligand for C-Mpl. It was shown to be the major regulator of megakaryocytopoiesis and platelet formation. Defects in c-MPL are a cause of congenital amegakaryocytic thrombocytopenia which is a disease characterized by isolated thrombocytopenia and Megakaryocytopenia with no physical anomalies. Defects in c-MPL also cause thrombocythemia type 2 and myelofibrosis with myeloid metaplasia.