C-MPL/TPO-R Protein, Rat, Recombinant (hFc)

Name: C-MPL/TPO-R Protein, Rat, Recombinant (hFc)
Brand: TargetMol
SKU: TMPY-05423
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: MPL proto-oncogene, thrombopoietin receptor, MPL) Copy Product Info

Synonyms: MPL proto-oncogene, thrombopoietin receptor, MPL

Catalog No. TMPY-05423 Copy Product Info

C-MPL Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 80.7 kDa and the accession number is A0A1W2Q6N1.

C-MPL/TPO-R Protein, Rat, Recombinant (hFc)

Pack Size	Price	USA Stock	Global Stock
5 µg	$47	-	In Stock
10 µg	$74	-	In Stock
20 µg	$118	-	In Stock
50 µg	$228	-	In Stock
100 µg	$392	7-10 days	7-10 days
200 µg	$670	7-10 days	7-10 days
500 µg	$1,350	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:92.2%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Information

Bioactivity

Bioactivity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	C-MPL Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 80.7 kDa and the accession number is A0A1W2Q6N1.
Species	Rat
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	A6JZI7
Construction	A DNA sequence encoding the rat MPL (XP_001072502.1) (Met1-Ala500) was expressed with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Gln 22
Protein Purity	> 95 % as determined by SDS-PAGE.
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	MPL proto-oncogene, thrombopoietin receptor, MPL
Research Background	CD11, also known as c-MPL, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. It is expressed at a low level in a large number of cells of hematopoietic origin. C-MPL is homologous with members of the hematopoietic receptor superfamily. The presence of anti-sense oligodeoxynucleotides of C-Mpl inhibited megakaryocyte colony formation. Thrombopoietin is the ligand for C-Mpl. It was shown to be the major regulator of megakaryocytopoiesis and platelet formation. Defects in c-MPL are a cause of congenital amegakaryocytic thrombocytopenia which is a disease characterized by isolated thrombocytopenia and Megakaryocytopenia with no physical anomalies. Defects in c-MPL also cause thrombocythemia type 2 and myelofibrosis with myeloid metaplasia.

Chemical Properties

Molecular Weight

80.7 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.