Powder: -20°C for 3 years | In solvent: -80°C for 1 year
2-Deoxy-D-galactose, a glucose analog, impedes glycolysis, thereby inhibiting tumor growth, and interferes with fucosylation of glycomacromolecules, which impairs memory consolidation in learning tasks. Additionally, this compound hinders the fucosylation of glycoproteins in vivo [1].
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Description | 2-Deoxy-D-galactose, a glucose analog, impedes glycolysis, thereby inhibiting tumor growth, and interferes with fucosylation of glycomacromolecules, which impairs memory consolidation in learning tasks. Additionally, this compound hinders the fucosylation of glycoproteins in vivo [1]. |
In vitro | 2-Deoxy-D-galactose undergoes rapid phosphorylation within the first 30 minutes at a concentration of 1 mM/L over 5 hours, then the rate declines to around 20% of the initial rate in the remaining time in ascites hepatoma cells [4]. |
In vivo | Administration of 2-Deoxy-D-galactose (380 mg/kg; i.p.; six administrations) significantly reduced the levels of UMP, UDPG, and UDP galactose in rat livers [1]. When injected intracerebroventricularly at doses ranging from 2-8 μM, it impaired PAR 30 minutes before the acquisition trial, with a notable effect at 4 μM and a 15-minute delay following administration [3]. |
Molecular Weight | 164.16 |
Formula | C6H12O5 |
CAS No. | 1949-89-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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2-Deoxy-D-galactose 1949-89-9 inhibitor inhibit