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PXS-6302 hydrochloride

Catalog No. T60438L CAS 2584947-79-3

Synonyms: PXS-6302 hydrochloride （2584947-54-4 Free base）

PXS-6302 hydrochloride is a potent irreversible lysine oxidase (LOX) inhibitor, inhibiting Bovine LOX, rh LOXL1, rh LOXL2, rh LOXL3, and rh LOXL4 with IC50 of 3.7 μM, 3.4 μM, 0.4 μM, 1.5 μM, and 0.3 μM, respectively. PXS-6302 hydrochloride penetrates easily through the skin and is able to reduce collagen accumulation, significantly improving the appearance of scars.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

PXS-6302 hydrochloride Chemical Structure

PXS-6302 hydrochloride, CAS 2584947-79-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 228.00
2 mg	In stock	$ 343.00
5 mg	In stock	$ 575.00
10 mg	In stock	$ 823.00
25 mg	In stock	$ 1,450.00
50 mg	In stock	$ 1,980.00
100 mg	In stock	$ 2,630.00

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Purity: 99.89%

Biological Description

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Storage & Solubility Information

Description	PXS-6302 hydrochloride is a potent irreversible lysine oxidase (LOX) inhibitor, inhibiting Bovine LOX, rh LOXL1, rh LOXL2, rh LOXL3, and rh LOXL4 with IC50 of 3.7 μM, 3.4 μM, 0.4 μM, 1.5 μM, and 0.3 μM, respectively. PXS-6302 hydrochloride penetrates easily through the skin and is able to reduce collagen accumulation, significantly improving the appearance of scars.
In vitro	PXS-6302 hydrochloride exhibits high permeability in monolayer cells, such as Caco-2 or MDCKII cells[1].
In vivo	PXS-6302 hydrochloride inhibits LOX, reduces cross-linking, and improves the appearance of scars in porcine excision and burn models[1]. In a mouse injury model, topical application of PXS-6302 hydrochloride (1.5%, water-in-oil cream; 500 mg cream applied to 16 cm2; topical; once daily for 28 days) reduces collagen deposition and cross-linked proteins in the fibrotic tissue[1]. Additionally, PXS-6302 hydrochloride (0.5%, 1.5%, or 3%, water-in-oil ointment; 400 mg ointment applied to 16 cm2; topical; once daily for 12 weeks) significantly improves the appearance of scars without reducing tissue strength in a porcine injury model under local application[1].

Synonyms	PXS-6302 hydrochloride （2584947-54-4 Free base）
Molecular Weight	301.71
Formula	C10H11ClF3NO2S
CAS No.	2584947-79-3

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (165.72 mM)

References and Literature

1. Chaudhari N, et al. Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis. Nat Commun. 2022 Sep 22;13(1):5555.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library

Related Products

Related compounds with same targets

Pinusolide ER-34122 Phenidone 3'-Demethylnobiletin Picrinine COX-2/15-LOX-IN-2 COX-2/15-LOX-IN-4 ZD-2138

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PXS-6302 hydrochloride 2584947-79-3 Metabolism Lipoxygenase PXS6302 Hydrochloride 2584947-54-4 Free base PXS-6302 Hydrochloride 2584947-54-4 PXS-6302 hydrochloride （2584947-54-4 Free base） PXS 6302 Hydrochloride inhibitor inhibit

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