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PXS-6302 hydrochloride

Name: PXS-6302 hydrochloride
Brand: TargetMol
SKU: T60438L
Price: 228 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60438LCas No. 2584947-79-3

Alias PXS-6302 hydrochloride (2584947-54-4 Free base)

PXS-6302 hydrochloride is a potent irreversible lysine oxidase (LOX) inhibitor, inhibiting Bovine LOX, rh LOXL1, rh LOXL2, rh LOXL3, and rh LOXL4 with IC50 of 3.7 μM, 3.4 μM, 0.4 μM, 1.5 μM, and 0.3 μM, respectively. PXS-6302 hydrochloride penetrates easily through the skin and is able to reduce collagen accumulation, significantly improving the appearance of scars.

PXS-6302 hydrochloride

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Purity: 99.98%

Catalog No. T60438LAlias PXS-6302 hydrochloride (2584947-54-4 Free base)Cas No. 2584947-79-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$228	In Stock	In Stock
2 mg	$343	In Stock	In Stock
5 mg	$575	In Stock	In Stock
10 mg	$823	In Stock	In Stock
25 mg	$1,450	In Stock	In Stock
50 mg	$1,980	In Stock	In Stock
100 mg	$2,630	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.98%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	PXS-6302 hydrochloride is a potent irreversible lysine oxidase (LOX) inhibitor, inhibiting Bovine LOX, rh LOXL1, rh LOXL2, rh LOXL3, and rh LOXL4 with IC50 of 3.7 μM, 3.4 μM, 0.4 μM, 1.5 μM, and 0.3 μM, respectively. PXS-6302 hydrochloride penetrates easily through the skin and is able to reduce collagen accumulation, significantly improving the appearance of scars.
In vitro	PXS-6302 hydrochloride exhibits high permeability in monolayer cells, such as Caco-2 or MDCKII cells[1].
In vivo	PXS-6302 hydrochloride inhibits LOX, reduces cross-linking, and improves the appearance of scars in porcine excision and burn models[1]. In a mouse injury model, topical application of PXS-6302 hydrochloride (1.5%, water-in-oil cream; 500 mg cream applied to 16 cm2; topical; once daily for 28 days) reduces collagen deposition and cross-linked proteins in the fibrotic tissue[1]. Additionally, PXS-6302 hydrochloride (0.5%, 1.5%, or 3%, water-in-oil ointment; 400 mg ointment applied to 16 cm2; topical; once daily for 12 weeks) significantly improves the appearance of scars without reducing tissue strength in a porcine injury model under local application[1].
Synonyms	PXS-6302 hydrochloride (2584947-54-4 Free base)

Chemical Properties

Molecular Weight	301.71
Formula	C₁₀H₁₁ClF₃NO₂S
Cas No.	2584947-79-3
Smiles	S(C(/C(=C/CN)/F)(F)F)(=O)(=O)C1=CC=CC=C1.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (165.72 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1.67 mg/mL (5.54 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3144 mL	16.5722 mL	33.1444 mL	165.7221 mL
5 mM	0.6629 mL	3.3144 mL	6.6289 mL	33.1444 mL
10 mM	0.3314 mL	1.6572 mL	3.3144 mL	16.5722 mL
20 mM	0.1657 mL	0.8286 mL	1.6572 mL	8.2861 mL
50 mM	0.0663 mL	0.3314 mL	0.6629 mL	3.3144 mL
100 mM	0.0331 mL	0.1657 mL	0.3314 mL	1.6572 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc