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DHODH-IN-23

Name: DHODH-IN-23
Brand: TargetMol
SKU: T67875
Price: 395 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T67875 Copy Product Info

Purity: 99.7%

🥰Excellent

DHODH-IN-23 is a DHODH inhibitor with oral activity. DHODH-IN-23 is often used in cancer research.

DHODH-IN-23

Copy Product Info

🥰Excellent

Catalog No. T67875

DHODH-IN-23 is a DHODH inhibitor with oral activity. DHODH-IN-23 is often used in cancer research.

Cas No. 1346705-53-0

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Pack Size	Price	USA Stock	Global Stock
5 mg	$48	In Stock	In Stock
10 mg	$76	In Stock	In Stock
25 mg	$173	In Stock	In Stock
50 mg	$273	In Stock	In Stock
100 mg	$395	-	In Stock
500 mg	Preferential	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.7%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	DHODH-IN-23 is a DHODH inhibitor with oral activity. DHODH-IN-23 is often used in cancer research.
In vitro	DHODH-IN-23 (72 h) inhibits proliferation of acute myeloid leukemia cells.[1] DHODH-IN-23 (0.1-3 μM; 72 h) induces the expression of CDllb in THP-1 cells.[1]
In vivo	DHODH-IN-23 (30 mg/kg; oral; twice daily for 21 days) exhibits anti-tumor activity in the MV411 xenograft mouse model.[1]

Chemical Properties

Molecular Weight	441.88
Formula	C₂₄H₂₁ClFNO₄
Cas No.	1346705-53-0
Smiles	ClC=1C=C(C=C(F)C1NC(=O)C2=C(C(O)=O)C=CC=C2)C3=CC(OCCCC)=CC=C3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 112.5 mg/mL (254.59 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2631 mL	11.3153 mL	22.6306 mL	113.1529 mL
5 mM	0.4526 mL	2.2631 mL	4.5261 mL	22.6306 mL
10 mM	0.2263 mL	1.1315 mL	2.2631 mL	11.3153 mL
20 mM	0.1132 mL	0.5658 mL	1.1315 mL	5.6576 mL
50 mM	0.0453 mL	0.2263 mL	0.4526 mL	2.2631 mL
100 mM	0.0226 mL	0.1132 mL	0.2263 mL	1.1315 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc