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Methoxyacetic acid

Name: Methoxyacetic acid
Brand: TargetMol
SKU: T37982
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37982Cas No. 625-45-6

Methoxyacetic acid is a metabolite of ethylene glycol monomethyl ether with HDAC inhibitory activity, inhibiting prostate cancer cell growth by inducing growth arrest and apoptosis.

Methoxyacetic acid

😃Good

Catalog No. T37982Cas No. 625-45-6

Methoxyacetic acid is a metabolite of ethylene glycol monomethyl ether with HDAC inhibitory activity, inhibiting prostate cancer cell growth by inducing growth arrest and apoptosis.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Appearance:Liquid

Color:Transparent

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COA

Product Introduction

Bioactivity

Description

Methoxyacetic acid is a metabolite of ethylene glycol monomethyl ether with HDAC inhibitory activity, inhibiting prostate cancer cell growth by inducing growth arrest and apoptosis.

In vivo

Methods: Male Fischer rats were treated with Methoxyacetic acid (30, 100, 300 mg/kg, gavage) for 5 consecutive days in the first week and then 3 times a day after a weekend break to study its effects on the rats. Results: Compared with the control group, Methoxyacetic acid administration led to a significant decrease in body weight in rats, severe degeneration of the testicular germinal epithelium, a significant decrease in thymus size, depletion of thymic cortical lymphoid components, and a decrease in bone marrow cellularity. At a dose of 300 mg/kg, it even led to a decrease in red blood cell count, hemoglobin concentration, packed cell volume, and white blood cell count. [1]

Chemical Properties

Molecular Weight	90.08
Formula	C₃H₆O₃
Cas No.	625-45-6
Smiles	COCC(O)=O
Relative Density.	1.174 g/cm3 at 25℃ (lit.)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (888.1 mM), Sonication is recommended.

H2O: 80 mg/mL (888.1 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (36.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	11.1012 mL	55.5062 mL	111.0124 mL	555.0622 mL
5 mM	2.2202 mL	11.1012 mL	22.2025 mL	111.0124 mL
10 mM	1.1101 mL	5.5506 mL	11.1012 mL	55.5062 mL
20 mM	0.5551 mL	2.7753 mL	5.5506 mL	27.7531 mL
50 mM	0.2220 mL	1.1101 mL	2.2202 mL	11.1012 mL
100 mM	0.1110 mL	0.5551 mL	1.1101 mL	5.5506 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc