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RAGE Protein, Human, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is Q15109-1.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 μg | $48 | 7-10 days | 7-10 days | |
| 10 μg | $75 | 7-10 days | 7-10 days | |
| 20 μg | $118 | 7-10 days | 7-10 days | |
| 50 μg | $229 | 7-10 days | 7-10 days | |
| 100 μg | $386 | 7-10 days | 7-10 days | |
| 200 μg | $682 | 7-10 days | 7-10 days | |
| 500 μg | $1,430 | 7-10 days | 7-10 days |
| Biological Activity | Human AGER, His Tag immobilized on CM5 Chip can bind Human HMGB1, His Tag with an affinity constant of 0.19 μM as determined in SPR assay (Biacore T200). |
| Description | RAGE Protein, Human, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is Q15109-1. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-His |
| Accession Number | Q15109-1 |
| Synonyms | RAGE,AGER,advanced glycosylation end product-specific receptor |
| Construction | Ala23- Ala344 |
| Protein Purity | > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
| Molecular Weight | 35.3 kDa (Predicted); 50-60 kDa (Due to glycosylation) |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
| Research Background | The receptor for advanced glycation end products (AGER) is an oncogenic transmembranous receptor up-regulated in various human cancers. AGER promotes proliferation, migration, and inhibits apoptosis of squamous cervical cancer and might function as a tumor promoter in cervical cancer. Our study provides novel evidence for a potential role of AGER in bridging human papillomavirus (HPV)-induced inflammation and cervical cancer. |
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