Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SCFSkp2-IN-2, a Skp2 inhibitor, exhibits a dissociation constant (K_D) of 28.77 μM. It demonstrates antitumor activities by inducing apoptosis in non-small cell lung cancer (NSCLC) cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 39.00 | |
10 mg | In stock | $ 64.00 | |
25 mg | In stock | $ 128.00 | |
50 mg | In stock | $ 213.00 | |
100 mg | In stock | $ 372.00 | |
500 mg | In stock | $ 869.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 43.00 |
Description | SCFSkp2-IN-2, a Skp2 inhibitor, exhibits a dissociation constant (K_D) of 28.77 μM. It demonstrates antitumor activities by inducing apoptosis in non-small cell lung cancer (NSCLC) cells. |
Targets&IC50 | Skp2:28.77 μM(kd) |
In vitro |
SCFSkp2-IN-2 (Compound AAA-237) (0.3-3 μM ; 24-72 h) binds directly to Skp2, leading to degradation of Skp2 by the proteasome.AAA-237 has no significant effect on Skp2 mRNA expression, but has a time-dependent inhibitory effect on Skp2 protein expression in NSCLC cells.[1] SCFSkp2-IN-2 (0.3-3 μM ; 24-72 h) inhibited the proliferation of A549 and H1299 cells in a dose- and time-dependent manner.[1] SCFSkp2-IN-2 (0.3-3 μM ; 24-72 h) blocks the cell cycle at the G0/G1 checkpoint by regulating the Skp2-Cip/Kip and PI3K/Akt-FOXO1 signaling pathways.[1] SCFSkp2-IN-2 (0.3-3 μM ; 24-72 h) induces apoptosis in A549 and H1299 cells in a dose- and time-dependent manner.[1] SCFSkp2-IN-2 (0.3 μM ; 1-7 days) induces NSCLC cell senescence.[1] |
In vivo | SCFSkp2-IN-2 (Compound AAA-237) (15 or 45 mg/kg ; i.p. ; daily for 14 days) showed antitumor activity in a mouse model of lung cancer A549 xenograft.[1] |
Molecular Weight | 312.37 |
Formula | C17H20N4O2 |
CAS No. | 1375060-02-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 112.5 mg/mL (360.2 mM ), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. More
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SCFSkp2-IN-2 1375060-02-8 Apoptosis Ubiquitination E1/E2/E3 Enzyme SCFSkp2IN2 inhibitor inhibit