Shopping Cart
Remove All
Your shopping cart is currently empty
(D-Ser2)-Leu-Enkephalin-Thr
Copy Product Info
🥰Excellent
Catalog No. T22752L
(D-Ser2)-Leu-Enkephalin-Thr is a delta selective agent of opioid receptor and shows analgesic effects.
(D-Ser2)-Leu-Enkephalin-Thr
Copy Product Info🥰Excellent
Catalog No. T22752L
(D-Ser2)-Leu-Enkephalin-Thr is a delta selective agent of opioid receptor and shows analgesic effects.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $68 | In Stock | In Stock | |
| 5 mg | $153 | In Stock | In Stock | |
| 10 mg | $229 | In Stock | In Stock | |
| 25 mg | $413 | In Stock | In Stock | |
| 50 mg | $615 | In Stock | In Stock | |
| 100 mg | $876 | In Stock | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Appearance:Solid
Color:White
Contact us for more batch information
Product Introduction
(D-Ser2)-Leu-Enkephalin-Thr AI Summary
(D-Ser2)-Leu-Enkephalin-Thr exhibits bioactivity as a potent opioid receptor modulator with significant binding affinities and differential actions across multiple opioid receptor subtypes. For the guinea pig brain membrane, it shows an IC50 of 73.0 nM for the mu-opioid receptor, 1.3 nM for the delta-opioid receptor, and 600.0 nM for the kappa-opioid receptor. In terms of functional activity, it acts as an antagonist at mu 1 opioid receptors and an agonist at both mu 1 and delta 1 opioid receptors, exhibiting IC50 values of 406.0 nM (antagonism in guinea pig ileum) and 0.4 nM (agonism in guinea pig ileum and mouse vas deferens), respectively. Binding studies reveal Ki values of 31.0 nM for mu 1 and 4.8 nM for delta 1 opioid receptors. Additionally, the compound shows inhibitory activity in the mouse vas deferens both before and after beta-CNS-induced inactivation protection (IC50 values of 0.38 nM and 0.65 nM, respectively). (D-Ser2)-Leu-Enkephalin-Thr also demonstrates potent analgesic effects in mice after intracerebroventricular injection, with an AD50 of 130.0 pM. It shows low selectivity for mouse vas deferens versus guinea pig ileum (Selectivity = 0.001) but a higher binding preference for delta 1 over mu 1 opioid receptors (Ratio = 0.15). Furthermore, it stimulates [35S]GTP-gamma-S binding in rat delta opioid receptors expressed in C6 cells and displaces [3H]naltrindole with an activity of 93.0 nM..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | (D-Ser2)-Leu-Enkephalin-Thr is a delta selective agent of opioid receptor and shows analgesic effects. |
| Molecular Weight | 686.75 |
| Formula | C33H46N6O10 |
| Smiles | C[C@@H](O)[C@@H](C(O)=O)NC([C@H](CC(C)C)NC([C@H](CC1=CC=CC=C1)NC(CNC([C@@H](CO)NC([C@H](CC2=CC=C(O)C=C2)N)=O)=O)=O)=O)=O |
| Relative Density. | no data available |
| Sequence | Tyr-D-Ser-Gly-Phe-Leu-Thr |
| Sequence Short | YSGFLT |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy (D-Ser2)-Leu-Enkephalin-Thr | purchase (D-Ser2)-Leu-Enkephalin-Thr | (D-Ser2)-Leu-Enkephalin-Thr cost | order (D-Ser2)-Leu-Enkephalin-Thr | (D-Ser2)-Leu-Enkephalin-Thr chemical structure | (D-Ser2)-Leu-Enkephalin-Thr formula | (D-Ser2)-Leu-Enkephalin-Thr molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.