Fenaminosulf

Fenaminosulf is a plant immune regulator and mutagen. It modulates immune recognition and signal transduction by inhibiting key kinases such as Xa21 and PBL19, impacting hormone metabolism, phenylpropanoid biosynthesis, and plant-pathogen interaction-related gene expression. Fenaminosulf affects rice shoot growth and tumor formation in a concentration-dependent manner. It induces mutations in bacterial systems and causes chromosomal aberrations in plants, though it does not exhibit mutagenic activity or lethality in Drosophila melanogaster. Rat studies show inconsistent carcinogenic properties of Fenaminosulf.

Fenaminosulf can induce mutagenic activity in Salmonella typhimurium and interact with DNA in Bacillus subtilis. Additionally, Fenaminosulf is capable of causing chromosomal aberrations in higher plant cells.

Fenaminosulf, when applied as a foliar spray at concentrations of 1.25-5 g/L every 7 days for a total of three applications, exhibits a concentration-dependent effect on Zizania latifolia: it enhances vegetative growth at 1.25 g/L and, after 100 days of treatment, increases gall formation rates to approximately 85% at 5 g/L and 75% at 2.5 g/L. Additionally, Fenaminosulf (10 mg/100 mL food medium; oral administration during mating and larval development phases) does not induce sex-linked recessive lethal mutations in Drosophila melanogaster. Further, when administered orally at 250 mg/kg in feed daily for 17 months, Fenaminosulf does not cause tumor formation in Sprague-Dawley rats.