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Bay 41-4109 (less active enantiomer)

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Catalog No. T10480Cas No. 476617-51-3

Bay 41-4109, a potent HBV inhibitor with an IC50 of 53 nM, exhibits greater activity compared to its less active enantiomer.

Bay 41-4109 (less active enantiomer)
Other Forms of Bay 41-4109 (less active enantiomer):

Bay 41-4109 (less active enantiomer)

😃Good
Catalog No. T10480Cas No. 476617-51-3
Bay 41-4109, a potent HBV inhibitor with an IC50 of 53 nM, exhibits greater activity compared to its less active enantiomer.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$2,2206-8 weeks6-8 weeks
50 mg$2,6806-8 weeks6-8 weeks
100 mg$3,2006-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
Bay 41-4109, a potent HBV inhibitor with an IC50 of 53 nM, exhibits greater activity compared to its less active enantiomer.
Targets&IC50
HBV:53 nM
In vivo
BAY 41-4109 exhibits dose-dependent reductions in viral DNA levels in both the liver and plasma, demonstrating effectiveness commensurate with 3TC. It also diminishes the hepatitis B virus core antigen (HBcAg) in the livers of HBV-transgenic mice. Pharmacokinetic analyses reveal swift absorption, a 30% bioavailability in mice, and dose-proportional plasma concentrations, reaching approximately 60% in rats and dogs [1]. Furthermore, BAY41-4109 disrupts in vivo virus production through a mechanism that interacts with the viral capsid [2].
Chemical Properties
Molecular Weight395.76
FormulaC18H13ClF3N3O2
Cas No.476617-51-3
SmilesC(OC)(=O)C=1[C@H](NC(=NC1C)C2=C(F)C=C(F)C=N2)C3=C(Cl)C=C(F)C=C3
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 37 mg/mL (93.49 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5268 mL12.6339 mL25.2678 mL126.3392 mL
5 mM0.5054 mL2.5268 mL5.0536 mL25.2678 mL
10 mM0.2527 mL1.2634 mL2.5268 mL12.6339 mL
20 mM0.1263 mL0.6317 mL1.2634 mL6.3170 mL
50 mM0.0505 mL0.2527 mL0.5054 mL2.5268 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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