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Pyrithioxin dihydrochloride

Name: Pyrithioxin dihydrochloride
Brand: TargetMol
SKU: T20735
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20735Cas No. 10049-83-9

Alias Vitamin B6 disulfide dihydrochloride, Pyritinol dihydrochloride, Pyrithioxine hydrochloride, Pyrithioxine HCl

Pyrithioxin dihydrochloride (Pyrithioxine HCl) has anti-nociceptive and anti-allodynic effects, can promote the metabolism of glucose and amino acids in the brain, improve systemic assimilation, and can be used to study neurological diseases such as atherosclerosis. Pyrithioxin dihydrochloride can induce severe cholestatic hepatitis.

Pyrithioxin dihydrochloride

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Purity: 98%

Catalog No. T20735Alias Vitamin B6 disulfide dihydrochloride, Pyritinol dihydrochloride, Pyrithioxine hydrochloride, Pyrithioxine HClCas No. 10049-83-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$32	-	In Stock
100 mg	$48	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98%

Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Pyrithioxin dihydrochloride (Pyrithioxine HCl) has anti-nociceptive and anti-allodynic effects, can promote the metabolism of glucose and amino acids in the brain, improve systemic assimilation, and can be used to study neurological diseases such as atherosclerosis. Pyrithioxin dihydrochloride can induce severe cholestatic hepatitis.
In vivo	METHODS: The effect of Pyrithioxin dihydrochloride on children with learning disabilities was tested under strict double-blind conditions in 67 students in a class with learning disabilities aged 11 to 16 years who received either Pyrithioxin dihydrochloride (300 mg, 24 hours) or placebo for 6 months. Effects on cognitive function. RESULTS:Pyrithioxin dihydrochloride had different effects on different subjects. None of the 22 parameters showed a statistically significant treatment effect in terms of mean performance. Variability was significantly higher in the Pyrithioxin dihydrochloride group (F = 1.85-2.33, P less than 0.05 and less than 0.02, respectively). [1]
Synonyms	Vitamin B6 disulfide dihydrochloride, Pyritinol dihydrochloride, Pyrithioxine hydrochloride, Pyrithioxine HCl

Chemical Properties

Molecular Weight	441.39
Formula	C₁₆H₂₂Cl₂N₂O₄S₂
Cas No.	10049-83-9
Smiles	OC1=C(CO)C(CSSCC2=CN=C(C)C(O)=C2CO)=CN=C1C.Cl.Cl
Relative Density.	1.448g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (113.28 mM), Sonication is recommended.

H2O: 40 mg/mL (90.62 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2656 mL	11.3279 mL	22.6557 mL	113.2785 mL
5 mM	0.4531 mL	2.2656 mL	4.5311 mL	22.6557 mL
10 mM	0.2266 mL	1.1328 mL	2.2656 mL	11.3279 mL
20 mM	0.1133 mL	0.5664 mL	1.1328 mL	5.6639 mL
50 mM	0.0453 mL	0.2266 mL	0.4531 mL	2.2656 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0227 mL	0.1133 mL	0.2266 mL	1.1328 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc