a-b

PS210 is a potent and selective activator of PDK1 (Kd: 3 μM), specifically targeting the PIF-binding pocket of PDK1 without affecting other protein kinases such as S6K, PKB/Akt, or GSK3. Its prodrug, PS423, serves as a substrate-selective inhibitor of PDK1 in cells, inhibiting the phosphorylation and activation of S6K.

SMARCA-BD ligand 1 for Protac is a compound that binds to SMARCA2, the BAF ATPase subunit, utilizing Protac technology to degrade SMARCA2.

ALOIN Inhibits Interleukin (IL)-1β-Stimulated IL-8 Production in KB Cells.

tert-Butyl 6-hydroxy-2-aza-bicyclo[2.2.1]heptane-2-carboxylate, with CAS No. 207405-59-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. tert-Butyl 6-hydroxy-2-aza-bicyclo[2.2.1]heptane-2-carboxylate provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

a,b-Elemolic acid is a useful organic compound for research related to life sciences and the catalog number is T125129.

(R)-a-Terpinyl b-D-glucoside is a useful organic compound for research related to life sciences. The catalog number is T126338 and the CAS number is 114673-99-3.

Citroside A or B is a useful organic compound for research related to life sciences and the catalog number is T131127.

A 58365 B, an angiotensin converting enzyme (ACE) inhibitor isolated from Streptomyces chromofuscus, is used for the treatment of congestive heart failure and hypertension.

(S)-(3,5-Dioxa-4-phosphacyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-5H-dibenz[b,f]azepine is a useful organic compound for research related to life sciences. The catalog number is T67268 and the CAS number is 942939-38-0.

Leucinostatin, a mixture of components A and B, constitutes the primary elements of a unique nonapeptide complex synthesized by Paecilomyces lilacinus, functioning as antibiotics [1].

MAO-A/B-IN-3 (Compound 12) demonstrated moderate permeability in in vitro experiments, with rates recorded at 16.49 nm/s in Caco2 cells and 103.16 nm/s in MDCK cells. The compound exhibited a high plasma protein binding rate of 90.97%, indicative of strong binding, suggesting it has an extended half-life and slow excretion characteristics.

1-(a,b)-O-methyl-3,5-di-(O-p-toluoyl)-2-deoxy-D-ribose is a Carbohydrate derivative.

HLA-B*0801-bindingEBV peptide, derived from the Epstein-Barr virus (EBV) epitope FLRGRAYGL, interacts with the HLA-B*0801 molecule. This peptide is presented to CD8+ T cells via HLA-B*0801, thereby activating a specific immune response.

Alpha-Belladonnine is a useful organic compound for research related to life sciences and the catalog number is T124601.

SMARCA-BD ligand 1 for Protac dihydrochloride binds to the BAF ATPase subunit SMARCA2 and is used for degrading SMARCA2 based on PROTAC.

Azido-PEG3-Ala-Boc, a PEG-based linker for PROTACs, joins two essential ligands necessary for forming PROTAC molecules and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

AM-Imidazole-PA-Boc is an alkyl chain-derived PROTAC linker used for the synthesis of PROTAC IRAK4 degrader-1[1].

EA-B2L is an effective degrader of glutathione S-transferase (GSTP) with a DC50 of 48 μM. It is composed of Ethacrynic acid linked to Boc2Lys. EA-B2L plays a significant role in cancer research.

OA-Br-1 is an orally active, selective inhibitor of PTP1B with an IC50 value of 7.08 μM. It induces apoptosis and exhibits broad-spectrum anti-cancer cell proliferation activity. OA-Br-1 exerts anti-breast cancer effects both in vitro and in vivo through the PTP1B/PI3K/AKT signaling pathway.

AA-BR-157 is a PROTAC degrader targeting metallothionein 2A (MT2A) with a DC50 of 190 nM. It downregulates DIAPH3, a protein involved in cytoskeletal and cellular movement regulation, inhibiting cell migration in MDA-MB-231 and U-87 MG cell lines. Additionally, AA-BR-157 modulates zinc homeostasis in MDA-MB-231 cells. (Pink: ligand for target protein MT2A ligand 1; Black: linker; Blue: ligand for VHL E3 ligase).

1-Bromonaphthalene is an organic compound with the formula C10H7Br. Under normal conditions, the substance is a colorless liquid.

Alpha-Boswellic acid (α-Boswellic acid) is a pentacyclic triterpenoid natural product extracted from frankincense, exhibiting anticonvulsant and anticancer effects, and in animals, it prevents and reduces Alzheimer's disease markers, making it valuable for Alzheimer's disease research.

MCPA-butyl is a biochemical.