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Obexelimab
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Catalog No. T81624Cas No. 1690307-05-1
Alias XmAb5871, AMG729, AMG 729
Obexelimab (XmAb5871) is a bifunctional monoclonal antibody that binds CD19 and FcyRIIb, inhibits B-cells, plasmoblasts, and plasma cells, and may be used in the study of autoimmune diseases such as systemic lupus erythematosus.
Obexelimab
Obexelimab
Copy Product Info😃Good
Catalog No. T81624Alias XmAb5871, AMG729, AMG 729Cas No. 1690307-05-1
Obexelimab (XmAb5871) is a bifunctional monoclonal antibody that binds CD19 and FcyRIIb, inhibits B-cells, plasmoblasts, and plasma cells, and may be used in the study of autoimmune diseases such as systemic lupus erythematosus.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $293 | - | In Stock | |
| 5 mg | $723 | - | In Stock | |
| 10 mg | $986 | - | In Stock | |
| 25 mg | $1,490 | - | In Stock | |
| 50 mg | $1,970 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98% (SDS-PAGE); 100% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | Obexelimab (XmAb5871) is a bifunctional monoclonal antibody that binds CD19 and FcyRIIb, inhibits B-cells, plasmoblasts, and plasma cells, and may be used in the study of autoimmune diseases such as systemic lupus erythematosus. |
| In vitro | Obexelimab induces the expression of genes associated with the apoptotic pathway and promotes apoptosis in B cells. [1] 10 μg/mL Obexelimab, treated for 3 min, inhibited B cell activation and its function by inhibiting BCR-mediated calcium influx and promoting phosphorylation of FcγRIIb. [2] |
| In vivo | 10 mg/kg Obexelimab, injected intraperitoneally twice weekly, suppressed autoimmune responses in immunodeficient mice implanted with peripheral blood mononuclear cells (PBMC) from rheumatoid arthritis (RA) patients. [2] |
| Synonyms | XmAb5871, AMG729, AMG 729 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | CD19 |
| Molecular Weight | 147.44 kDa |
| Cas No. | 1690307-05-1 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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