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Omeprazole sulfide

Name: Omeprazole sulfide
Brand: TargetMol
SKU: T2687
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2687Cas No. 73590-85-9

Alias Ufiprazole, Omeprazole metabolite Omeprazole sulfide

Omeprazole sulfide (Ufiprazole), a metabolite of Omeprazole, functions as a proton pump inhibitor.

Omeprazole sulfide

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Purity: 98.83%

Catalog No. T2687Alias Ufiprazole, Omeprazole metabolite Omeprazole sulfideCas No. 73590-85-9

Omeprazole sulfide (Ufiprazole), a metabolite of Omeprazole, functions as a proton pump inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:98.83%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Omeprazole sulfide AI Summary

Omeprazole sulfide exhibits diverse bioactivities, including significant antibacterial, antiviral, and enzymatic inhibitory properties. It has demonstrated antibacterial activity against Helicobacter pylori with a minimum bactericidal concentration (MBC) of 32.0 µg/ml and inhibits urease activity in H. pylori, CCUG 15818, in a dose-dependent manner at concentrations of 1 µM, 10 µM, and 100 µM. Additionally, Omeprazole sulfide acts as an agonist at the recombinant BRS-3 receptor in HEK293 cells, showing an EC50 of 3900.0 nM for intracellular calcium mobilization and achieving 64.0% of the maximum response compared to a reference compound. The compound also exhibits antiviral properties by blocking Ebola virus entry (AC50 values ranging from 0.631 µM to 5623.4 nM) and inhibiting SARS-CoV-2-induced cytotoxicity in Caco-2 cells (inhibition of 39.12% at 10 µM after 48 hours). It further shows inhibitory effects on SARS-CoV-2 3CL-Pro protease at 20 µM with a minor inhibition percentage and cytotoxicity inhibition in VERO-6 cells. Lastly, Omeprazole sulfide inhibits human HDAC6, presenting 62.83% inhibition with a commercial peptide substrate and 7.26% with a custom peptide substrate, highlighting its potential as a multi-target bioactive compound with diverse therapeutic applications. The lipophilicity value (log Ko) of the compound is 0.0..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Omeprazole sulfide (Ufiprazole), a metabolite of Omeprazole, functions as a proton pump inhibitor.
Synonyms	Ufiprazole, Omeprazole metabolite Omeprazole sulfide

Chemical Properties

Molecular Weight	329.42
Formula	C₁₇H₁₉N₃O₂S
Cas No.	73590-85-9
Smiles	S(CC1=C(C)C(OC)=C(C)C=N1)C=2NC=3C(N2)=CC=C(OC)C3
Relative Density.	1.28 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (151.78 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.07 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0356 mL	15.1782 mL	30.3564 mL	151.7819 mL
5 mM	0.6071 mL	3.0356 mL	6.0713 mL	30.3564 mL
10 mM	0.3036 mL	1.5178 mL	3.0356 mL	15.1782 mL
20 mM	0.1518 mL	0.7589 mL	1.5178 mL	7.5891 mL
50 mM	0.0607 mL	0.3036 mL	0.6071 mL	3.0356 mL
100 mM	0.0304 mL	0.1518 mL	0.3036 mL	1.5178 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc