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CCK-B Receptor Antagonist 2

Name: CCK-B Receptor Antagonist 2
Brand: TargetMol
SKU: T10707
Rating: 4.5 (1 reviews)

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Catalog No. T10707Cas No. 155412-88-7

CCK-B Receptor Antagonist 2 is a potent and orally active antagonist of Gastrin/CCK-B (IC50: 0.43 nM). It also inhibits gastrin/CCK-A activity (IC50: 1.82 μM).

CCK-B Receptor Antagonist 2

😃Good

Catalog No. T10707Cas No. 155412-88-7

CCK-B Receptor Antagonist 2 is a potent and orally active antagonist of Gastrin/CCK-B (IC50: 0.43 nM). It also inhibits gastrin/CCK-A activity (IC50: 1.82 μM).

Pack Size	Price	Availability
5 mg	$446	6-8 weeks
25 mg	$1,430	6-8 weeks
50 mg	$1,860	6-8 weeks
100 mg	$2,500	6-8 weeks

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Product Introduction

Bioactivity

Description	CCK-B Receptor Antagonist 2 is a potent and orally active antagonist of Gastrin/CCK-B (IC50: 0.43 nM). It also inhibits gastrin/CCK-A activity (IC50: 1.82 μM).
Targets&IC50	Gastrin/CCK-B:0.43 nM , Gastrin/CCK-A:1.82 μM
In vivo	CCK-B Receptor Antagonist 2 (0.1 μmol/kg; i.v.) inhibits pentagastrin-induced gastric acid secretion in anesthetized rats, with an ED50 of 8.3 nmol/kg.

Chemical Properties

Molecular Weight	484.55
Formula	C₂₇H₂₈N₆O₃
Cas No.	155412-88-7
Relative Density.	1.29 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (515.94 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0638 mL	10.3189 mL	20.6377 mL	103.1885 mL
5 mM	0.4128 mL	2.0638 mL	4.1275 mL	20.6377 mL
10 mM	0.2064 mL	1.0319 mL	2.0638 mL	10.3189 mL
20 mM	0.1032 mL	0.5159 mL	1.0319 mL	5.1594 mL
50 mM	0.0413 mL	0.2064 mL	0.4128 mL	2.0638 mL
100 mM	0.0206 mL	0.1032 mL	0.2064 mL	1.0319 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc