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IMAB027

Catalog No. T78296 CAS 1650599-68-0

Synonyms: ASP1650

IMAB027 (ASP1650) is a specific monoclonal antibody targeting CLDN6 (Claudin 6), a membrane protein of tight junctions aberrantly overexpressed in multiple human cancers, notably in ovarian cancers. This compound exhibits anti-tumor properties and induces apoptosis specifically in CLDN6-positive ovarian and testicular cancer cell lines [1].

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IMAB027

IMAB027, CAS 1650599-68-0

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	IMAB027 (ASP1650) is a specific monoclonal antibody targeting CLDN6 (Claudin 6), a membrane protein of tight junctions aberrantly overexpressed in multiple human cancers, notably in ovarian cancers. This compound exhibits anti-tumor properties and induces apoptosis specifically in CLDN6-positive ovarian and testicular cancer cell lines [1].
In vitro	IMAB027 selectively binds to CLDN6 rather than closely related family members such as Claudins 3, 4, and 9 [1]. In ovarian and testicular cancer cell lines expressing CLDN6+, IMAB027 induces selective antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) in target cells [1].
In vivo	IMAB027 can reduce tumor growth and enhance overall survival rates in mice transplanted with human CLDN6+ cells [1].

Synonyms	ASP1650
Molecular Weight	N/A
CAS No.	1650599-68-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

IMAB027 1650599-68-0 ASP-1650 ASP 1650 ASP1650 IMAB-027 IMAB 027 inhibitor inhibit

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