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RS47 (Compound 1a) is a small molecule (Kd = 1.1 μM) that specifically targets RelB, selectively inhibiting the non-canonical NF-κB pathway by disrupting RelB binding to target DNA. It exhibits antitumour activity in vivo and in vitro and may be used in studies of colorectal cancer and B-cell lymphoma.


| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $41 | - | In Stock | |
| 5 mg | $97 | - | In Stock | |
| 10 mg | $137 | - | In Stock | |
| 25 mg | $233 | - | In Stock | |
| 50 mg | $392 | - | In Stock | |
| 100 mg | $568 | - | In Stock | |
| 200 mg | $792 | - | In Stock |
| Description | RS47 (Compound 1a) is a small molecule (Kd = 1.1 μM) that specifically targets RelB, selectively inhibiting the non-canonical NF-κB pathway by disrupting RelB binding to target DNA. It exhibits antitumour activity in vivo and in vitro and may be used in studies of colorectal cancer and B-cell lymphoma. |
| Synonyms | RS-47, RS 47 |
| Molecular Weight | 354.43 |
| Formula | C18H18N4O2S |
| Cas No. | 301655-16-3 |
| Smiles | OC1=CC=C(O)C(=C1)C(=NNC=2N=CN=C3SC4=C(C32)CCCC4)C |
| Storage | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (56.43 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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