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Nortriptyline
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Catalog No. T73844Cas No. 72-69-5
Nortriptyline is an antidepressant compound that enhances corticosteroid sensitivity of blood T-cells in patients with chronic obstructive pulmonary disease (COPD) and may be used for smoking cessation.
Nortriptyline
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Purity: 99.8%
Catalog No. T73844Cas No. 72-69-5
Nortriptyline is an antidepressant compound that enhances corticosteroid sensitivity of blood T-cells in patients with chronic obstructive pulmonary disease (COPD) and may be used for smoking cessation.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $39 | In Stock | In Stock | |
| 5 mg | $62 | In Stock | In Stock | |
| 10 mg | $98 | In Stock | In Stock | |
| 25 mg | $158 | In Stock | In Stock | |
| 50 mg | $228 | In Stock | In Stock | |
| 100 mg | $372 | In Stock | In Stock | |
| 500 mg | $869 | Backorder | Backorder |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.8%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Nortriptyline is an antidepressant compound that enhances corticosteroid sensitivity of blood T-cells in patients with chronic obstructive pulmonary disease (COPD) and may be used for smoking cessation. |
| In vitro | In human TCCSUP and mouse MBT-2 bladder cancer cells, Nortriptyline (at concentrations of 6.25 μM, 12.5 μM, 25 μM, 50 μM, and 100 μM; treatment durations of 24, 48, or 72 hours) exhibited cytotoxic effects on both TCCSUP and MBT-2 cells[3]. |
| In vivo | In adult male C3H/HeN mice (weighing 25-30 grams, aged 2-3 months) inoculated with MBT-2 cells, Nortriptyline (administered at doses of 10 or 20 mg/kg; via intraperitoneal injection; once daily; for three weeks) was able to suppress tumor growth in mice engrafted with MBT-2 cells[3]. |
| Molecular Weight | 263.38 |
| Formula | C19H21N |
| Cas No. | 72-69-5 |
| Smiles | C=1C=CC2=C(C1)C(=CCCNC)C=3C=CC=CC3CC2 |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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