store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MFI8 is a compound that regulates mitochondrial fission and can be used to study aging.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 198.00 | |
10 mg | In stock | $ 328.00 | |
25 mg | In stock | $ 648.00 | |
50 mg | In stock | $ 1,110.00 | |
100 mg | In stock | $ 1,610.00 | |
500 mg | In stock | $ 3,220.00 |
Description | MFI8 is a compound that regulates mitochondrial fission and can be used to study aging. |
Targets&IC50 | mitochondrial:4.8 μM (EC50) |
In vitro |
At a concentration of 20 μM for a duration of 6 hours, MFI8 significantly reduces mitochondrial aspect ratio with an EC50 of 4.8 μM. It achieves this by inhibiting mitochondrial function through mitofusins, subsequently promoting mitochondrial fission [1]. MFI8 possesses functional groups that adhere to the pharmacophore model standards. It interacts with mitofusins, facilitating mitochondrial fission [1]. Binding to the HR2 domain of MFN2, MFI8 modulates MFN conformation and complexes, thereby altering mitochondrial function [1].In a concentration-responsive manner (0-20 μM; 6 hours), MFI8 increases caspase-3/7 activity, induces cytochrome c release, and reduces membrane potential in a mitotic protein-dependent manner. Additionally, the combination of MFI8 with BV6 SMAC, a mimic of the second mitochondrial-derived activator of caspases, induces DNA damage and cell death [1]. |
Molecular Weight | 275.77 |
Formula | C16H18ClNO |
CAS No. | 694488-83-0 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (290.10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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MFI8 694488-83-0 Metabolism Mitochondrial Metabolism inhibitor inhibit