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MFI8
🥰Excellent
Catalog No. T60503Cas No. 694488-83-0
MFI8 is a compound that regulates mitochondrial fission and can be used to study aging.
MFI8
🥰Excellent
Purity: 99.78%
Catalog No. T60503Cas No. 694488-83-0
MFI8 is a compound that regulates mitochondrial fission and can be used to study aging.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $71 | In Stock | In Stock | |
| 5 mg | $170 | In Stock | In Stock | |
| 10 mg | $281 | In Stock | In Stock | |
| 25 mg | $462 | In Stock | In Stock | |
| 50 mg | $630 | In Stock | In Stock | |
| 100 mg | $822 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $158 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.78%
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Product Introduction
Bioactivity
Chemical Properties
| Description | MFI8 is a compound that regulates mitochondrial fission and can be used to study aging. |
| Targets&IC50 | mitochondrial:4.8 μM (EC50) |
| In vitro | At a concentration of 20 μM for a duration of 6 hours, MFI8 significantly reduces mitochondrial aspect ratio with an EC50 of 4.8 μM. It achieves this by inhibiting mitochondrial function through mitofusins, subsequently promoting mitochondrial fission [1]. MFI8 possesses functional groups that adhere to the pharmacophore model standards. It interacts with mitofusins, facilitating mitochondrial fission [1]. Binding to the HR2 domain of MFN2, MFI8 modulates MFN conformation and complexes, thereby altering mitochondrial function [1].In a concentration-responsive manner (0-20 μM; 6 hours), MFI8 increases caspase-3/7 activity, induces cytochrome c release, and reduces membrane potential in a mitotic protein-dependent manner. Additionally, the combination of MFI8 with BV6 SMAC, a mimic of the second mitochondrial-derived activator of caspases, induces DNA damage and cell death [1]. |
| Molecular Weight | 275.77 |
| Formula | C16H18ClNO |
| Cas No. | 694488-83-0 |
| Smiles | CC(Nc1cccc(C)c1C)c1cc(Cl)ccc1O |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (290.10 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (11.97 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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