keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tianeptine metabolite MC5, an active derivative of the atypical antidepressant tianeptine produced through β-oxidation, exhibits selective G protein activation in bioluminescence resonance energy transfer (BRET) assays. Utilizing HEK293T cells expressing the human μ-opioid receptor (MOR) over the human δ-opioid receptor (DOR; EC50s = 0.454 and <100 µM, respectively), it demonstrates specificity. Moreover, this metabolite reduces immobility in wild-type mice during the forced swim test at a dose of 30 mg/kg, an effect not observed in MOR knockout mice, suggesting its antidepressant-like activity is MOR-dependent.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 497.00 | |
5 mg | 35 days | $ 2,410.00 | |
10 mg | 35 days | $ 3,800.00 |
Description | Tianeptine metabolite MC5, an active derivative of the atypical antidepressant tianeptine produced through β-oxidation, exhibits selective G protein activation in bioluminescence resonance energy transfer (BRET) assays. Utilizing HEK293T cells expressing the human μ-opioid receptor (MOR) over the human δ-opioid receptor (DOR; EC50s = 0.454 and >100 µM, respectively), it demonstrates specificity. Moreover, this metabolite reduces immobility in wild-type mice during the forced swim test at a dose of 30 mg/kg, an effect not observed in MOR knockout mice, suggesting its antidepressant-like activity is MOR-dependent. |
Molecular Weight | 430.88 |
Formula | C19H20ClN2O4S.Na |
CAS No. | 115220-11-6 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: Slightly soluble
Methanol: Slightly soluble
DMSO: Slightly soluble
Dichloromethane: Slightly soluble
You can also refer to dose conversion for different animals. More
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Tianeptine Metabolite MC5 sodium 115220-11-6 inhibitor inhibit