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BN82002 hydrochloride

Name: BN82002 hydrochloride
Brand: TargetMol
SKU: T38447
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38447Cas No. 1049740-43-3

Alias BN 82002 hydrochloride

BN82002 hydrochloride is a CDC25 phosphatase inhibitor that inhibits the phosphatase activity of recombinant human CDC25A, B, and C in vitro, arresting the cell cycle and reducing tumour growth in mice.

BN82002 hydrochloride

😃Good

Catalog No. T38447Alias BN 82002 hydrochlorideCas No. 1049740-43-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$39	-	In Stock
5 mg	$89	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Viscous

Color:Orange

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COA

Product Introduction

Bioactivity

Description	BN82002 hydrochloride is a CDC25 phosphatase inhibitor that inhibits the phosphatase activity of recombinant human CDC25A, B, and C in vitro, arresting the cell cycle and reducing tumour growth in mice.
Targets&IC50	CDC25A:2.4 μM, CDC25B3:6.3 μM, CDC25B2:3.9 μM, CDC25C:5.4 μM, CDC25C-cat:4.6 μM
In vitro	Methods: RAW264.7 cells were treated with BN82002 hydrochloride (0-100 μM, 24 hours), and cell viability was measured by MTT assay. Results: BN82002 hydrochloride reduced cell viability by 20% at a concentration of 100 μM. [2]
Synonyms	BN 82002 hydrochloride

Chemical Properties

Molecular Weight	395.88
Formula	C₁₉H₂₆ClN₃O₄
Cas No.	1049740-43-3
Smiles	Cl.O=N(=O)C1=CC=C(C=C1)CCN(C)CC2=CC(=CC(OC)=C2O)N(C)C
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | store at 4°C | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (505.2 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (12.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5260 mL	12.6301 mL	25.2602 mL	126.3009 mL
5 mM	0.5052 mL	2.5260 mL	5.0520 mL	25.2602 mL
10 mM	0.2526 mL	1.2630 mL	2.5260 mL	12.6301 mL
20 mM	0.1263 mL	0.6315 mL	1.2630 mL	6.3150 mL
50 mM	0.0505 mL	0.2526 mL	0.5052 mL	2.5260 mL
100 mM	0.0253 mL	0.1263 mL	0.2526 mL	1.2630 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc