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Mc-Gly-Gly-Phe-Gly-PAB-OH

🥰Excellent
Catalog No. T40257Cas No. 2632342-05-1
Alias Mc-GGFG-PAB-OH

Mc-Gly-Gly-Phe-Gly-PAB-OH is a cleavable linker used for the synthesis of antibody-drug conjugates (ADCs).

Mc-Gly-Gly-Phe-Gly-PAB-OH
Other Forms of Mc-Gly-Gly-Phe-Gly-PAB-OH:
Mc-Gly-Gly-Phe-Gly-PAB-OH TFAT77833
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Mc-Gly-Gly-Phe-Gly-PAB-OH

🥰Excellent
Purity: 97.38%
Catalog No. T40257Alias Mc-GGFG-PAB-OHCas No. 2632342-05-1
Mc-Gly-Gly-Phe-Gly-PAB-OH is a cleavable linker used for the synthesis of antibody-drug conjugates (ADCs).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$45-In Stock
5 mg$76-In Stock
10 mg$123-In Stock
25 mg$228-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:97.38%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
Mc-Gly-Gly-Phe-Gly-PAB-OH is a cleavable linker used for the synthesis of antibody-drug conjugates (ADCs).
In vitro
ADCs consist of an antibody linked to an ADC cytotoxin via an ADC linker.
SynonymsMc-GGFG-PAB-OH
Chemical Properties
Molecular Weight634.68
FormulaC32H38N6O8
Cas No.2632342-05-1
Smiles[C@H](CC1=CC=CC=C1)(C(NCC(NC2=CC=C(CO)C=C2)=O)=O)NC(CNC(CNC(CCCCCN3C(=O)C=CC3=O)=O)=O)=O
Relative Density.1.328 g/cm3 (Predicted)
SequenceGly-Gly-Phe-Gly
Sequence ShortGGFG
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 200 mg/mL (315.12 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.5756 mL7.8780 mL15.7560 mL78.7799 mL
5 mM0.3151 mL1.5756 mL3.1512 mL15.7560 mL
10 mM0.1576 mL0.7878 mL1.5756 mL7.8780 mL
20 mM0.0788 mL0.3939 mL0.7878 mL3.9390 mL
50 mM0.0315 mL0.1576 mL0.3151 mL1.5756 mL
100 mM0.0158 mL0.0788 mL0.1576 mL0.7878 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

Mc-Gly-Gly-Phe-Gly-PAB-OHMcGlyGlyPheGlyPABOHMc Gly Gly Phe Gly PAB OHADCLinkerADC Linker
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