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Mc-Gly-Gly-Phe-Gly-PAB-OH

Name: Mc-Gly-Gly-Phe-Gly-PAB-OH
Brand: TargetMol
SKU: T40257
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40257Cas No. 2632342-05-1

Alias Mc-GGFG-PAB-OH

Mc-Gly-Gly-Phe-Gly-PAB-OH is a cleavable linker used for the synthesis of antibody-drug conjugates (ADCs).

Mc-Gly-Gly-Phe-Gly-PAB-OH

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Purity: 97.38%

Catalog No. T40257Alias Mc-GGFG-PAB-OHCas No. 2632342-05-1

Mc-Gly-Gly-Phe-Gly-PAB-OH is a cleavable linker used for the synthesis of antibody-drug conjugates (ADCs).

Pack Size	Price	Availability
2 mg	$45	In Stock
5 mg	$76	In Stock
10 mg	$123	In Stock
25 mg	$228	In Stock

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.38%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Mc-Gly-Gly-Phe-Gly-PAB-OH is a cleavable linker used for the synthesis of antibody-drug conjugates (ADCs).
In vitro	ADCs consist of an antibody linked to an ADC cytotoxin via an ADC linker.
Synonyms	Mc-GGFG-PAB-OH

Chemical Properties

Molecular Weight	634.68
Formula	C₃₂H₃₈N₆O₈
Cas No.	2632342-05-1
Smiles	[C@H](CC1=CC=CC=C1)(C(NCC(NC2=CC=C(CO)C=C2)=O)=O)NC(CNC(CNC(CCCCCN3C(=O)C=CC3=O)=O)=O)=O
Relative Density.	1.328 g/cm3 (Predicted)
Sequence	Gly-Gly-Phe-Gly
Sequence Short	GGFG

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200.00 mg/mL (315.12 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5756 mL	7.8780 mL	15.7560 mL	78.7799 mL
5 mM	0.3151 mL	1.5756 mL	3.1512 mL	15.7560 mL
10 mM	0.1576 mL	0.7878 mL	1.5756 mL	7.8780 mL
20 mM	0.0788 mL	0.3939 mL	0.7878 mL	3.9390 mL
50 mM	0.0315 mL	0.1576 mL	0.3151 mL	1.5756 mL
100 mM	0.0158 mL	0.0788 mL	0.1576 mL	0.7878 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc