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Tiagabine hydrochloride

Name: Tiagabine hydrochloride
Brand: TargetMol
SKU: T7000
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7000Cas No. 145821-59-6

Alias TGB hydrochloride, NO328 hydrochloride, NO050328 hydrochloride, Gabitril hydrochloride

Tiagabine hydrochloride (NO050328 hydrochloride) is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor.

Tiagabine hydrochloride

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Purity: 99.77%

Catalog No. T7000Alias TGB hydrochloride, NO328 hydrochloride, NO050328 hydrochloride, Gabitril hydrochlorideCas No. 145821-59-6

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$50	In Stock	In Stock
25 mg	$63	In Stock	In Stock
50 mg	$113	In Stock	In Stock
100 mg	$203	-	In Stock
200 mg	$331	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$47	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.77%

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COA

Product Introduction

Bioactivity

Description	Tiagabine hydrochloride (NO050328 hydrochloride) is the hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. A selective gamma-aminobutyric acid (GABA) reuptake inhibitor.
In vitro	Tiagabine is a potent inhibitor of GABA uptake into neurons and glial cells. It is involved in modulating GABA levels, especially in areas such as the hippocampus and thalamus[2]. Tiagabine not only affected the decay kinetics of the IPSCs, it also reduced the frequency of occurrence of both spontaneous and miniature IPSCs[4].
In vivo	Tiagabine offers a significant neuroprotection in global ischemia in gerbils when given 30 min before ischemia but not when given 3 h after ischemia[3].
Synonyms	TGB hydrochloride, NO328 hydrochloride, NO050328 hydrochloride, Gabitril hydrochloride

Chemical Properties

Molecular Weight	412.01
Formula	C₂₀H₂₅NO₂S₂·HCl
Cas No.	145821-59-6
Smiles	Cl.Cc1ccsc1\C(=C\CCN1CCC[C@H](C1)C(O)=O)c1sccc1C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 41.2 mg/mL (100 mM), Sonication is recommended.

H2O: 20.6 mg/mL (50 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.85 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4271 mL	12.1356 mL	24.2713 mL	121.3563 mL
5 mM	0.4854 mL	2.4271 mL	4.8543 mL	24.2713 mL
10 mM	0.2427 mL	1.2136 mL	2.4271 mL	12.1356 mL
20 mM	0.1214 mL	0.6068 mL	1.2136 mL	6.0678 mL
50 mM	0.0485 mL	0.2427 mL	0.4854 mL	2.4271 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0243 mL	0.1214 mL	0.2427 mL	1.2136 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc