Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BTM-3528 is a mitochondrial protease OMA1 activator that induces an overactivation of the mitochondrial integrated stress response (ISR). It promotes OMA1-dependent cleavage of DELE1 and OPA1, leading to mitochondrial fragmentation. Additionally, BTM-3528 triggers eIF2α kinase HRI activation, resulting in cell growth arrest and apoptosis. Demonstrating anticancer properties, it is effective against various DLBCL cell lines and exhibits in vivo inhibitory capabilities in a mouse model xenografted with human DLBCL SU-DHL-10 cells [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 1,670.00 | |
50 mg | 8-10 weeks | $ 2,180.00 | |
100 mg | 8-10 weeks | $ 2,800.00 |
Description | BTM-3528 is a mitochondrial protease OMA1 activator that induces an overactivation of the mitochondrial integrated stress response (ISR). It promotes OMA1-dependent cleavage of DELE1 and OPA1, leading to mitochondrial fragmentation. Additionally, BTM-3528 triggers eIF2α kinase HRI activation, resulting in cell growth arrest and apoptosis. Demonstrating anticancer properties, it is effective against various DLBCL cell lines and exhibits in vivo inhibitory capabilities in a mouse model xenografted with human DLBCL SU-DHL-10 cells [1]. |
Molecular Weight | 521.55 |
Formula | C24H19F4N3O2S2 |
CAS No. | 2054998-45-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BTM-3528 2054998-45-5 Metabolism Mitochondrial Metabolism inhibitor inhibit