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BTM-3528
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Catalog No. T78875Cas No. 2054998-45-5
Alias BTM3528, BTM 3528
BTM-3528 is an activator of the mitochondrial protease OMA1 with anticancer activity.BTM-3528 activates the ISR via the mitochondrial protease OMA1, inducing OMA1-dependent cleavage of DELE1 and OPA1 and mitochondrial fragmentation.BTM-3528 induces cell growth arrest and apoptosis.
BTM-3528
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Purity: 99.37%
Catalog No. T78875Alias BTM3528, BTM 3528Cas No. 2054998-45-5
BTM-3528 is an activator of the mitochondrial protease OMA1 with anticancer activity.BTM-3528 activates the ISR via the mitochondrial protease OMA1, inducing OMA1-dependent cleavage of DELE1 and OPA1 and mitochondrial fragmentation.BTM-3528 induces cell growth arrest and apoptosis.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $485 | - | In Stock | |
| 5 mg | $1,090 | - | In Stock | |
| 10 mg | $1,290 | - | In Stock | |
| 25 mg | $1,670 | - | In Stock | |
| 50 mg | $2,180 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.37%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | BTM-3528 is an activator of the mitochondrial protease OMA1 with anticancer activity.BTM-3528 activates the ISR via the mitochondrial protease OMA1, inducing OMA1-dependent cleavage of DELE1 and OPA1 and mitochondrial fragmentation.BTM-3528 induces cell growth arrest and apoptosis. |
| In vitro | Both BTM-3528 and BTM-3566 demonstrated potent, dose-dependent activity against DLBCL lines of varying genotypes, including MYC-rearranged (“double” and “triple” hit) lymphomas, with growth inhibition and IC >90%50 values of 0.16–0.57 μmol/L. [2] |
| In vivo | METHODS: BTM-3566 was tested in 9 human DLBCL patient-derived xenograft (PDX) models representing ABC and GCB DLBCL subtypes, treated with 20 mg/kg BTM-3566. RESULTS: All 3 mice in 6 of the 9 PDX models achieved CR, and when 27 mice from the treatment groups across the 9 models were combined, CR was observed in 66% (19/27), with an additional 4 mice experiencing partial remission (PR), 2 mice experiencing stable tumors, and 2 experiencing progressive disease. [2] |
| Synonyms | BTM3528, BTM 3528 |
| Molecular Weight | 521.55 |
| Formula | C24H19F4N3O2S2 |
| Cas No. | 2054998-45-5 |
| Smiles | O=C(O)C1=C(C=2C=CC=C(F)C2)C(=NN1C3=NC(=C(S3)SC(C)C)C=4C=CC(=CC4)C(F)(F)F)C |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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