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Ochratoxin α

Name: Ochratoxin α
Brand: TargetMol
SKU: T39339
Rating: 4.5 (1 reviews)

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Catalog No. T39339Cas No. 19165-63-0

Alias Ochratoxin alpha

Ochratoxin α (Ochratoxin alpha) is a degradation product of Ochratoxin A, used for studying Ochratoxin A degradation.

Ochratoxin α

😃Good

Catalog No. T39339Alias Ochratoxin alphaCas No. 19165-63-0

Ochratoxin α (Ochratoxin alpha) is a degradation product of Ochratoxin A, used for studying Ochratoxin A degradation.

Pack Size	Price	Availability	Quantity
2 mg	$311	5 days
5 mg	$426	7-10 days

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Product Introduction

Bioactivity

Description	Ochratoxin α (Ochratoxin alpha) is a degradation product of Ochratoxin A, used for studying Ochratoxin A degradation.
In vitro	The ROS level of Ochratoxin α (200-400 nM, 48 h) LX-2 cells was significantly increased, and the cell viability was decreased. [1] Ochratoxin α (2.0 μg/ml) significantly induced NLRP3 inflammasome activation and Caspase-1-dependent pyrodeath. The expression of proinflammatory cytokines (IL-6, TNF-α) and pyrogenic genes (GSDMD, IL-1β, IL-18) was increased and the secretion of MDCK cells was increased. [2]
In vivo	Ochratoxin α (200 and 1000 μg/kg orally) induced liver fibrosis in mice. [1] Mice with Ochratoxin α(1.0 and 2.0 mg/kg, intrabitoneal injection, once every two days for 14 days) showed renal histological injury and abnormal expression of renal fibrosis molecules (α-SMA, vimentin, TGF-β). Nod-like receptor protein 3 (NLRP3) inflammasome is activated and induces pyrodeath. [2]
Synonyms	Ochratoxin alpha

Chemical Properties

Molecular Weight	256.64
Formula	C₁₁H₉ClO₅
Cas No.	19165-63-0
Smiles	ClC1=C2C(=C(O)C(C(O)=O)=C1)C(=O)O[C@H](C)C2
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (467.58 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8965 mL	19.4825 mL	38.9651 mL	194.8254 mL
5 mM	0.7793 mL	3.8965 mL	7.7930 mL	38.9651 mL
10 mM	0.3897 mL	1.9483 mL	3.8965 mL	19.4825 mL
20 mM	0.1948 mL	0.9741 mL	1.9483 mL	9.7413 mL
50 mM	0.0779 mL	0.3897 mL	0.7793 mL	3.8965 mL
100 mM	0.0390 mL	0.1948 mL	0.3897 mL	1.9483 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc