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Ochratoxin α

Name: Ochratoxin α
Brand: TargetMol
SKU: T39339
Rating: 4.5 (1 reviews)

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Catalog No. T39339Cas No. 19165-63-0

Alias Ochratoxin alpha

Ochratoxin α (Ochratoxin alpha) is a degradation product of Ochratoxin A, used for studying Ochratoxin A degradation.

Ochratoxin α

😃Good

Catalog No. T39339Alias Ochratoxin alphaCas No. 19165-63-0

Ochratoxin α (Ochratoxin alpha) is a degradation product of Ochratoxin A, used for studying Ochratoxin A degradation.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$311	5 days	5 days
5 mg	$426	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Ochratoxin α (Ochratoxin alpha) is a degradation product of Ochratoxin A, used for studying Ochratoxin A degradation.
In vitro	The ROS level of Ochratoxin α (200-400 nM, 48 h) LX-2 cells was significantly increased, and the cell viability was decreased. [1] Ochratoxin α (2.0 μg/ml) significantly induced NLRP3 inflammasome activation and Caspase-1-dependent pyrodeath. The expression of proinflammatory cytokines (IL-6, TNF-α) and pyrogenic genes (GSDMD, IL-1β, IL-18) was increased and the secretion of MDCK cells was increased. [2]
In vivo	Ochratoxin α (200 and 1000 μg/kg orally) induced liver fibrosis in mice. [1] Mice with Ochratoxin α(1.0 and 2.0 mg/kg, intrabitoneal injection, once every two days for 14 days) showed renal histological injury and abnormal expression of renal fibrosis molecules (α-SMA, vimentin, TGF-β). Nod-like receptor protein 3 (NLRP3) inflammasome is activated and induces pyrodeath. [2]
Synonyms	Ochratoxin alpha

Chemical Properties

Molecular Weight	256.64
Formula	C₁₁H₉ClO₅
Cas No.	19165-63-0
Smiles	ClC1=C2C(=C(O)C(C(O)=O)=C1)C(=O)O[C@H](C)C2

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (467.58 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (19.48 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8965 mL	19.4825 mL	38.9651 mL	194.8254 mL
5 mM	0.7793 mL	3.8965 mL	7.7930 mL	38.9651 mL
10 mM	0.3897 mL	1.9483 mL	3.8965 mL	19.4825 mL
20 mM	0.1948 mL	0.9741 mL	1.9483 mL	9.7413 mL
50 mM	0.0779 mL	0.3897 mL	0.7793 mL	3.8965 mL
100 mM	0.0390 mL	0.1948 mL	0.3897 mL	1.9483 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc