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5-Bromouridine

🥰Excellent
Catalog No. T36894Cas No. 957-75-5
Alias 5-bromo uridine

5-Bromouridine is a uracil derivative with a broad spectrum of antitumor activity that induces apoptosis in cancer cells by inhibiting DNA synthesis.5-Bromouridine is also used as a marker for DNA and RNA, where the molecule is labeled with a radioisotope or pigment after being introduced into a DNA or RNA strand.

5-Bromouridine

5-Bromouridine

🥰Excellent
Purity: 99.89%
Catalog No. T36894Alias 5-bromo uridineCas No. 957-75-5
5-Bromouridine is a uracil derivative with a broad spectrum of antitumor activity that induces apoptosis in cancer cells by inhibiting DNA synthesis.5-Bromouridine is also used as a marker for DNA and RNA, where the molecule is labeled with a radioisotope or pigment after being introduced into a DNA or RNA strand.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
200 mg$30In StockIn Stock
500 mg$41In StockIn Stock
1 mL x 10 mM (in DMSO)$39In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.89%
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Product Introduction

Bioactivity
Description
5-Bromouridine is a uracil derivative with a broad spectrum of antitumor activity that induces apoptosis in cancer cells by inhibiting DNA synthesis.5-Bromouridine is also used as a marker for DNA and RNA, where the molecule is labeled with a radioisotope or pigment after being introduced into a DNA or RNA strand.
Synonyms5-bromo uridine
Chemical Properties
Molecular Weight323.1
FormulaC9H11BrN2O6
Cas No.957-75-5
SmilesO[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)NC(=O)C(Br)=C2
Relative Density.1.9322 g/cm3 (Estimated)
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 80 mg/mL (247.6 mM), Sonication is recommended.
PBS (pH 7.2): 2 mg/mL (6.19 mM), Sonication is recommended.
DMSO: 80 mg/mL (247.6 mM), Sonication is recommended.
DMF: 8 mg/mL (24.76 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (10.21 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
PBS (pH 7.2)/DMF/H2O/DMSO
1mg5mg10mg50mg
1 mM3.0950 mL15.4751 mL30.9502 mL154.7509 mL
5 mM0.6190 mL3.0950 mL6.1900 mL30.9502 mL
DMF/H2O/DMSO
1mg5mg10mg50mg
10 mM0.3095 mL1.5475 mL3.0950 mL15.4751 mL
20 mM0.1548 mL0.7738 mL1.5475 mL7.7375 mL
H2O/DMSO
1mg5mg10mg50mg
50 mM0.0619 mL0.3095 mL0.6190 mL3.0950 mL
100 mM0.0310 mL0.1548 mL0.3095 mL1.5475 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
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μL
2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

5-Bromouridine5Bromouridine5 Bromouridine
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