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Cabotegravir sodium
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Catalog No. T62328Cas No. 1051375-13-3
Alias S/GSK1265744 sodium, GSK-1265744 sodium, GSK1265744 sodium
Cabotegravir sodium (GSK-1265744) is an orally active, membrane-permeable HIV integrase inhibitor (IC₅₀ = 2.5 μM) and also an OAT1/OAT3 inhibitor (IC₅₀ = 0.81/0.41 μM). It inhibits HIV replication and may be used in AIDS research.
Cabotegravir sodium
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Purity: 99.63%
Catalog No. T62328Alias S/GSK1265744 sodium, GSK-1265744 sodium, GSK1265744 sodiumCas No. 1051375-13-3
Cabotegravir sodium (GSK-1265744) is an orally active, membrane-permeable HIV integrase inhibitor (IC₅₀ = 2.5 μM) and also an OAT1/OAT3 inhibitor (IC₅₀ = 0.81/0.41 μM). It inhibits HIV replication and may be used in AIDS research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $41 | - | In Stock | |
| 25 mg | $64 | - | In Stock | |
| 50 mg | $91 | - | In Stock | |
| 100 mg | $129 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $30 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.63%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Cabotegravir sodium (GSK-1265744) is an orally active, membrane-permeable HIV integrase inhibitor (IC₅₀ = 2.5 μM) and also an OAT1/OAT3 inhibitor (IC₅₀ = 0.81/0.41 μM). It inhibits HIV replication and may be used in AIDS research. |
| Targets&IC50 | OAT1:0.81 μM, HIV (ADA):2.5 nM, OAT3:0.41 μM |
| In vitro | In vitro experiments demonstrated that Cabotegravir sodium inhibits the strand transfer reaction catalyzed by HIV-1 integrase, with a half-maximal inhibitory concentration (IC₅₀) of 3.0 nM. In PBMCs (peripheral blood mononuclear cells), the drug exhibited antiviral half-maximal effective concentrations (EC₅₀) of 0.22 nM against the HIV-1 Ba-L strain and 0.34 nM against the NL432 strain. In MT-4 cells, EC₅₀ values were determined as 0.57 nM by the CellTiter-Glo method and 1.3 nM by the MTT method, while the EC₅₀ measured in the pseudotyped self-inactivating virus PHIV assay was 0.5 nM [3]. |
| In vivo | The half-life of Cabotegravir sodium in mice is 54 days, demonstrating a prolonged duration [1]. Cabotegravir (25 or 50 mg/kg, administered intravenously as a single or double dose) can protect Macaca mulatta (macaques) from SIVmac251 virus infection [4]. |
| Synonyms | S/GSK1265744 sodium, GSK-1265744 sodium, GSK1265744 sodium |
| Molecular Weight | 427.34 |
| Formula | C19H16F2N3NaO5 |
| Cas No. | 1051375-13-3 |
| Smiles | [Na+].C[C@H]1CO[C@@H]2Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c([O-])c3C(=O)N12 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (11.7 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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