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YM-53403

Name: YM-53403
Brand: TargetMol
SKU: T29187
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T29187Cas No. 851331-05-0

YM-53403 is an antiviral activity that effectively inhibits the replication of RSV strains belonging to subgroup A and subgroup B. It can be used to treat respiratory syncytial virus infections.

YM-53403

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Purity: 99.8%

Catalog No. T29187Cas No. 851331-05-0

YM-53403 is an antiviral activity that effectively inhibits the replication of RSV strains belonging to subgroup A and subgroup B. It can be used to treat respiratory syncytial virus infections.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$210	In Stock	In Stock
5 mg	$497	In Stock	In Stock
10 mg	$678	In Stock	In Stock
25 mg	$953	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.8%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description

YM-53403 is an antiviral activity that effectively inhibits the replication of RSV strains belonging to subgroup A and subgroup B. It can be used to treat respiratory syncytial virus infections.

In vitro

YM-53403 (0.2 μM) reduced plaque with EC50 was 0.20 ± 0.05 μM.[2]
YM-53403 (50 μM) inhibited the life cycle of RSV at around 8 h post-infection in time-dependent, suggesting an inhibitory effect on early transcription and/or replication of the RSV genome. YM-53403 is an attractive compound for the treatment of RSV infection because of its highly potent anti-RSV activity and the new mode of action.[2]

Chemical Properties

Molecular Weight	583.7
Formula	C₃₆H₂₉N₃O₃S
Cas No.	851331-05-0
Smiles	C(NC1CC1)(=O)C=2SC=3C=4C(N(C(=O)C5=CC=C(NC(=O)C6=C(C=CC=C6)C7=CC=CC=C7)C=C5)CCC3C2)=CC=CC4
Relative Density.	1.39 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (102.79 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7132 mL	8.5660 mL	17.1321 mL	85.6604 mL
5 mM	0.3426 mL	1.7132 mL	3.4264 mL	17.1321 mL
10 mM	0.1713 mL	0.8566 mL	1.7132 mL	8.5660 mL
20 mM	0.0857 mL	0.4283 mL	0.8566 mL	4.2830 mL
50 mM	0.0343 mL	0.1713 mL	0.3426 mL	1.7132 mL
100 mM	0.0171 mL	0.0857 mL	0.1713 mL	0.8566 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc