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MAO-B-IN-28 (compound 10e) is a potent hMAO-B inhibitor with an IC50 value of 1.9±0.5 nM, potentially serving as a candidate molecule for neurodegenerative disease research.


| Description | MAO-B-IN-28 (compound 10e) is a potent hMAO-B inhibitor with an IC50 value of 1.9±0.5 nM, potentially serving as a candidate molecule for neurodegenerative disease research. |
| In vitro | MAO-B-IN-28 (0.5-128 μM, 24 h) exhibits significant cytotoxicity against MCF-7 cells, while it shows no notable cytotoxic effects on MGC-803, HCT-116, or HepG2 cells. Additionally, MAO-B-IN-28 (0.5, 4 μM, 24 h) demonstrates no cytotoxicity to differentiated SH-SY5Y cells and HVSMC cells. Furthermore, MAO-B-IN-28 (2, 4 μM, 24 h) does not increase ROS levels or cause oxidative damage in differentiated SH-SY5Y cells. |
| Molecular Weight | 405.35 |
| Formula | C19H10F3NO4S |
| Cas No. | 3028096-72-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |

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