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PZ-II-029
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Catalog No. T28479Cas No. 164025-44-9
Alias PZII-029, PZ-II029, PZII029, PZ II-029, PZ II029
PZ-II-029 is a modulator of α6β3γ2-selective GABAA channel.
PZ-II-029
Copy Product Info🥰Excellent
Purity: 99.79%
Catalog No. T28479Alias PZII-029, PZ-II029, PZII029, PZ II-029, PZ II029Cas No. 164025-44-9
PZ-II-029 is a modulator of α6β3γ2-selective GABAA channel.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $48 | In Stock | In Stock | |
| 5 mg | $113 | In Stock | In Stock | |
| 10 mg | $179 | In Stock | In Stock | |
| 25 mg | $322 | In Stock | In Stock | |
| 50 mg | $496 | In Stock | In Stock | |
| 100 mg | $762 | In Stock | In Stock | |
| 500 mg | $1,530 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $213 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.79%
Appearance:Solid
Color:Yellow
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Product Introduction
PZ-II-029 AI Summary
PZ-II-029 exhibits significant pharmacokinetic and pharmacodynamic properties. Pharmacokinetically, it demonstrates metabolic stability in both human and mouse liver microsomes, characterized by specific half-lives and remaining percentages of the parent compound after certain durations. It also varies in solubility levels across different solutions. Pharmacodynamically, PZ-II-029 acts as a positive allosteric modulator on GABA-A receptors, especially showing enhanced potentiation on the alpha6beta3gamma2 subunit compared to other subunits. This effect leads to increased GABA-induced current amplitudes at specific holding potentials, with enhancement reaching up to 702% at varying concentrations. In vivo studies in Wistar rats indicate crucial parameters such as Cmax, Tmax, AUC, and terminal elimination half-life in both plasma and brain compartments, following different administration routes. Additionally, the compound demonstrates a brain-to-plasma AUC ratio and oral bioavailability in both plasma and brain after oral gavage administration..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PZ-II-029 is a modulator of α6β3γ2-selective GABAA channel. |
| Synonyms | PZII-029, PZ-II029, PZII029, PZ II-029, PZ II029 |
| Molecular Weight | 321.33 |
| Formula | C18H15N3O3 |
| Cas No. | 164025-44-9 |
| Smiles | O=C1C=2C(C=3C(NC2)=CC(OC)=CC3)=NN1C4=CC=C(OC)C=C4 |
| Relative Density. | 1.35 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (155.6 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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