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Cobolimab (TSR-022) is a potent monoclonal antibody to TIM-3. Cobolimab induces internalization of TIM-3 with an IC50 value of 0.4464 nM. Cobolimab has antitumor activity and can be used to study advanced/metastatic melanoma and advanced hepatocellular carcinoma.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 249.00 | |
5 mg | In stock | $ 647.00 | |
10 mg | In stock | $ 970.00 |
Description | Cobolimab (TSR-022) is a potent monoclonal antibody to TIM-3. Cobolimab induces internalization of TIM-3 with an IC50 value of 0.4464 nM. Cobolimab has antitumor activity and can be used to study advanced/metastatic melanoma and advanced hepatocellular carcinoma. |
Targets&IC50 | TIM3:0.4464 nM |
In vitro |
Cobolimab (0.0001-10 nM; 3 days) promotes dose-dependent internalization of TIM-3 in pre-activated T cells, with an IC50 value of 0.4464 nM[4]. Cobolimab (20 µg/mL; 24 hours) significantly increases the content of CD8+ T cells by inhibiting TIM-3[3]. |
Synonyms | TSR-022, GSK4069889 |
Molecular Weight | N/A |
CAS No. | 2022215-65-0 |
store at low temperature
store at -80°C
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Cobolimab 2022215-65-0 Others GSK-4069889 TSR 022 TSR-022 TSR022 GSK4069889 GSK 4069889 inhibitor inhibit