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Cobolimab
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Catalog No. T77149Cas No. 2022215-65-0
Alias TSR-022, GSK4069889
Cobolimab (TSR-022) is a potent monoclonal antibody to TIM-3. Cobolimab induces internalization of TIM-3 with an IC50 value of 0.4464 nM. Cobolimab has antitumor activity and can be used to study advanced/metastatic melanoma and advanced hepatocellular carcinoma.
Cobolimab
Cobolimab
Copy Product Info😃Good
Catalog No. T77149Alias TSR-022, GSK4069889Cas No. 2022215-65-0
Cobolimab (TSR-022) is a potent monoclonal antibody to TIM-3. Cobolimab induces internalization of TIM-3 with an IC50 value of 0.4464 nM. Cobolimab has antitumor activity and can be used to study advanced/metastatic melanoma and advanced hepatocellular carcinoma.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $249 | In Stock | In Stock | |
| 5 mg | $647 | In Stock | In Stock | |
| 10 mg | $970 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:> 95%
Appearance:Liquid
Color:Transparent
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| Description | Cobolimab (TSR-022) is a potent monoclonal antibody to TIM-3. Cobolimab induces internalization of TIM-3 with an IC50 value of 0.4464 nM. Cobolimab has antitumor activity and can be used to study advanced/metastatic melanoma and advanced hepatocellular carcinoma. |
| Targets&IC50 | TIM3:0.4464 nM |
| In vitro | Cobolimab (0.0001-10 nM; 3 days) promotes dose-dependent internalization of TIM-3 in pre-activated T cells with an IC50 of 0.4464 nM[4], and at 20 µg/mL for 24 hours, significantly increases the content of CD8+ T cells by inhibiting TIM-3[3]. |
| Synonyms | TSR-022, GSK4069889 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | TIM-3/HAVCR2/CD366 |
| Molecular Weight | 142.84 kDa |
| Cas No. | 2022215-65-0 |
| Isotype | Human IgG4SP kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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