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Cobolimab (Synonyms: TSR-022, GSK4069889)

Catalog No. T77149 Copy Product Info
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Cobolimab (TSR-022) is a potent monoclonal antibody to TIM-3. Cobolimab induces internalization of TIM-3 with an IC50 value of 0.4464 nM. Cobolimab has antitumor activity and can be used to study advanced/metastatic melanoma and advanced hepatocellular carcinoma.

Cobolimab

Copy Product Info
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Catalog No. T77149
Synonyms TSR-022, GSK4069889

Cobolimab (TSR-022) is a potent monoclonal antibody to TIM-3. Cobolimab induces internalization of TIM-3 with an IC50 value of 0.4464 nM. Cobolimab has antitumor activity and can be used to study advanced/metastatic melanoma and advanced hepatocellular carcinoma.

Cobolimab
Cas No. 2022215-65-0
Pack SizePriceUSA StockGlobal StockQuantity
1 mg$249In StockIn Stock
5 mg$647In StockIn Stock
10 mg$970-In Stock
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Batch Information

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Purity:> 95%
Appearance:Liquid
Color:Transparent
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Product Introduction

Bioactivity
Description
Cobolimab (TSR-022) is a potent monoclonal antibody to TIM-3. Cobolimab induces internalization of TIM-3 with an IC50 value of 0.4464 nM. Cobolimab has antitumor activity and can be used to study advanced/metastatic melanoma and advanced hepatocellular carcinoma.
Targets&IC50
TIM3:0.4464 nM
In vitro
Cobolimab (0.0001-10 nM; 3 days) promotes dose-dependent internalization of TIM-3 in pre-activated T cells with an IC50 of 0.4464 nM[4], and at 20 µg/mL for 24 hours, significantly increases the content of CD8+ T cells by inhibiting TIM-3[3].
SynonymsTSR-022, GSK4069889
Reactivity
Human
Application
Functional assay
Antibody Type
Monoclonal
FormulationSupplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
Endotoxin<1.0 EU/mg
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Gene ID
Uniprot ID
TargetTIM-3/HAVCR2/CD366
Chemical Properties
Molecular Weight142.84 kDa
Cas No.2022215-65-0
Antibody Information
IsotypeHuman IgG4SP kappa
Recommended Isotype Control
Storage & Solubility Information
Storagestore at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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