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Cobolimab
(Synonyms: TSR-022, GSK4069889) Copy Product Info
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Synonyms: TSR-022, GSK4069889
Catalog No. T77149 Copy Product Info
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Cobolimab (TSR-022) is a potent monoclonal antibody to TIM-3. Cobolimab induces internalization of TIM-3 with an IC50 value of 0.4464 nM. Cobolimab has antitumor activity and can be used to study advanced/metastatic melanoma and advanced hepatocellular carcinoma.
Cas No. 2022215-65-0
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $249 | In Stock | In Stock | |
| 5 mg | $647 | In Stock | In Stock | |
| 10 mg | $970 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:> 95%
Appearance:Liquid
Color:Transparent
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Chemical Properties
Antibody Information
Storage & Solubility Information
| Description | Cobolimab (TSR-022) is a potent monoclonal antibody to TIM-3. Cobolimab induces internalization of TIM-3 with an IC50 value of 0.4464 nM. Cobolimab has antitumor activity and can be used to study advanced/metastatic melanoma and advanced hepatocellular carcinoma. |
| Targets & IC50 | TIM3:0.4464 nM |
| In vitro | Cobolimab (0.0001-10 nM; 3 days) promotes dose-dependent internalization of TIM-3 in pre-activated T cells with an IC50 of 0.4464 nM[4], and at 20 µg/mL for 24 hours, significantly increases the content of CD8+ T cells by inhibiting TIM-3[3]. |
| Endotoxin | <1.0 EU/mg |
| Synonyms | TSR-022, GSK4069889 |
| Reactivity | Human |
| Verified Activity | Immobilized Human TIM-3/KIM-3/HAVCR2 Protein (His) (TMPY-01621) at 1 μg/mL (100 μL/well) can bind Cobolimab. The EC50 is 5.13 ng/mL.  |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | TIM-3/HAVCR2/CD366 |
| Molecular Weight | 142.84 kDa |
| Cas No. | 2022215-65-0 |
| Isotype | Human IgG4SP kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Cobolimab chemical structure | Cobolimab in vitro | Cobolimab molecular weight
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