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SIAIS178

SIAIS178
SIAIS178, a potent and selective degrader of BCR-ABL based on PROTAC technology, exhibits an IC50 of 24 nM.
Catalog No. T12907Cas No. 2376047-73-1

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SIAIS178

Catalog No. T12907Cas No. 2376047-73-1

SIAIS178, a potent and selective degrader of BCR-ABL based on PROTAC technology, exhibits an IC50 of 24 nM.
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Pack SizePriceAvailabilityQuantity
1 mg$166Backorder
5 mg$397Backorder
10 mg$539Backorder
50 mg$1,610Backorder
100 mg$2,280Backorder
200 mgInquiryBackorder
500 mgInquiryBackorder
1 mL x 10 mM (in DMSO)$438Backorder
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Product Introduction

Bioactivity
Description
SIAIS178, a potent and selective degrader of BCR-ABL based on PROTAC technology, exhibits an IC50 of 24 nM.
Targets&IC50
BCR-ABL:24 nM, VHL:24 nM
Chemical Properties
Molecular Weight1012.68
FormulaC50H62ClN11O6S2
Cas No.2376047-73-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 300 mg/mL (296.24 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.9875 mL4.9374 mL9.8748 mL49.3739 mL
5 mM0.1975 mL0.9875 mL1.9750 mL9.8748 mL
10 mM0.0987 mL0.4937 mL0.9875 mL4.9374 mL
20 mM0.0494 mL0.2469 mL0.4937 mL2.4687 mL
50 mM0.0197 mL0.0987 mL0.1975 mL0.9875 mL
100 mM0.0099 mL0.0494 mL0.0987 mL0.4937 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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