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SIAIS178

Name: SIAIS178
Brand: TargetMol
SKU: T12907
Rating: 4.5 (1 reviews)

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Catalog No. T12907Cas No. 2376047-73-1

SIAIS178, a potent and selective degrader of BCR-ABL based on PROTAC technology, exhibits an IC50 of 24 nM.

SIAIS178

😃Good

Catalog No. T12907Cas No. 2376047-73-1

SIAIS178, a potent and selective degrader of BCR-ABL based on PROTAC technology, exhibits an IC50 of 24 nM.

Pack Size	Price	Availability
1 mg	$166	Backorder
5 mg	$397	Backorder
10 mg	$539	Backorder
50 mg	$1,610	Backorder
100 mg	$2,280	Backorder
200 mg	Inquiry	Backorder
500 mg	Inquiry	Backorder
1 mL x 10 mM (in DMSO)	$438	Backorder

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Product Introduction

Bioactivity

Description	SIAIS178, a potent and selective degrader of BCR-ABL based on PROTAC technology, exhibits an IC50 of 24 nM.
Targets&IC50	VHL:24 nM, BCR-ABL:24 nM

Chemical Properties

Molecular Weight	1012.68
Formula	C₅₀H₆₂ClN₁₁O₆S₂
Cas No.	2376047-73-1
Relative Density.	1.335 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 300 mg/mL (296.24 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9875 mL	4.9374 mL	9.8748 mL	49.3739 mL
5 mM	0.1975 mL	0.9875 mL	1.9750 mL	9.8748 mL
10 mM	0.0987 mL	0.4937 mL	0.9875 mL	4.9374 mL
20 mM	0.0494 mL	0.2469 mL	0.4937 mL	2.4687 mL
50 mM	0.0197 mL	0.0987 mL	0.1975 mL	0.9875 mL
100 mM	0.0099 mL	0.0494 mL	0.0987 mL	0.4937 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc