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Abelacimab
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Catalog No. T76894Cas No. 2098724-83-3
Alias MAA868, MAA 868
Abelacimab (MAA868), a fully human IgG1 monoclonal antibody that binds to and blocks the activation of FXI, is an anticoagulant used in the study of thromboembolic diseases.
Abelacimab
Abelacimab
😃Good
Catalog No. T76894Alias MAA868, MAA 868Cas No. 2098724-83-3
Abelacimab (MAA868), a fully human IgG1 monoclonal antibody that binds to and blocks the activation of FXI, is an anticoagulant used in the study of thromboembolic diseases.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $228 | In Stock | In Stock | |
| 5 mg | $629 | In Stock | - | |
| 10 mg | $993 | 7-10 days | 7-10 days | |
| 25 mg | $1,470 | 7-10 days | 7-10 days | |
| 50 mg | $1,980 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Abelacimab (MAA868), a fully human IgG1 monoclonal antibody that binds to and blocks the activation of FXI, is an anticoagulant used in the study of thromboembolic diseases. |
| In vitro | Abelacimab prolonged clotting time and decreased human plasma thrombin levels in a concentration-dependent manner over a concentration range of 0.0001 to 1 μM. [1] |
| In vivo | Subcutaneous injections of 3-30 mg/kg Abelacimab , days 1, 85, and 114, demonstrated potent and long-lasting anticoagulant effects in crab-eating monkeys, significantly prolonged the aPTT, and had a favorable safety profile, with no significant signs of toxicity or bleeding observed. In addition, intravenous, 0.6 mg/kg Abelacimab also demonstrated excellent anticoagulant activity in the FXI-/- C57BL/6 mouse model of ferric chloride-induced thrombosis, preventing carotid artery occlusion. [1] |
| Synonyms | MAA868, MAA 868 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | F11/Factor XI |
| Molecular Weight | 144.32 kDa |
| Cas No. | 2098724-83-3 |
| Color | Transparent |
| Appearance | Liquid |
| Isotype | IgG1 |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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