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Nonabine

Name: Nonabine
Brand: TargetMol
SKU: T28187
Price: 142 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T28187Cas No. 16985-03-8

Nonabine is a compound with strong antiemetic properties that can be used to prevent nausea and vomiting associated with cancer chemotherapy.

Nonabine

🥰Excellent

Purity: 99.94%

Catalog No. T28187Cas No. 16985-03-8

Nonabine is a compound with strong antiemetic properties that can be used to prevent nausea and vomiting associated with cancer chemotherapy.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$142	In Stock	In Stock
5 mg	$350	In Stock	In Stock
10 mg	$530	In Stock	In Stock
25 mg	$859	In Stock	In Stock
50 mg	$1,180	In Stock	In Stock
100 mg	$1,590	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.94%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

Nonabine is a compound with strong antiemetic properties that can be used to prevent nausea and vomiting associated with cancer chemotherapy.

In vivo

Nonabine is a chromenol structurally related to the cannabinoids which has shown antiemetic efficacy in clinical trials. Nonabine also produced sedative clinical effects, but with an EEG profile that resembled that reportedly caused by cannabinoids. In contrast to cannabinoids, nonabine did not cause changes of mood or perception, suggesting that nonabine lacks the potential for social abuse at antiemetic doses.[1]

Chemical Properties

Molecular Weight	379.54
Formula	C₂₅H₃₃NO₂
Cas No.	16985-03-8
Smiles	OC1=C2C(=CC(C)(C)OC2=CC(C(C(CCCCC)C)C)=C1)C=3C=CN=CC3
Relative Density.	1.047g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (144.91 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6348 mL	13.1738 mL	26.3477 mL	131.7384 mL
5 mM	0.5270 mL	2.6348 mL	5.2695 mL	26.3477 mL
10 mM	0.2635 mL	1.3174 mL	2.6348 mL	13.1738 mL
20 mM	0.1317 mL	0.6587 mL	1.3174 mL	6.5869 mL
50 mM	0.0527 mL	0.2635 mL	0.5270 mL	2.6348 mL
100 mM	0.0263 mL	0.1317 mL	0.2635 mL	1.3174 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc