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ODN 2007

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Catalog No. T74905Cas No. 455348-63-7
Alias ODN-2007, ODN2007

ODN 2007 sodium is a class B CpG oligodeoxynucleotide that functions as a Toll-like receptor ligand, robustly activating innate immune signaling pathways and serving as an effective immunomodulator and vaccine adjuvant, with demonstrated capacity to enhance immune responses across mammals, fish, and humans, and defined by the sequence 5'-TCGTCGTTGTCGTTTTGTCGTT-3' for reproducible immunological studies.

ODN 2007

ODN 2007

😃Good
Catalog No. T74905Alias ODN-2007, ODN2007Cas No. 455348-63-7
ODN 2007 sodium is a class B CpG oligodeoxynucleotide that functions as a Toll-like receptor ligand, robustly activating innate immune signaling pathways and serving as an effective immunomodulator and vaccine adjuvant, with demonstrated capacity to enhance immune responses across mammals, fish, and humans, and defined by the sequence 5'-TCGTCGTTGTCGTTTTGTCGTT-3' for reproducible immunological studies.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$832-4 weeks2-4 weeks
5 mg$1432-4 weeks2-4 weeks
10 mg$2432-4 weeks2-4 weeks
50 mgInquiry2-4 weeks2-4 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
ODN 2007 sodium is a class B CpG oligodeoxynucleotide that functions as a Toll-like receptor ligand, robustly activating innate immune signaling pathways and serving as an effective immunomodulator and vaccine adjuvant, with demonstrated capacity to enhance immune responses across mammals, fish, and humans, and defined by the sequence 5'-TCGTCGTTGTCGTTTTGTCGTT-3' for reproducible immunological studies.
In vitro
In avian macrophage models (MQ-NCSU, HD11), treatment with ODN 2007 (1-5 μg/mL) upregulated IFN-γ, IFN-β, and IL-1β mRNA levels. In HD11 cells, 10 μg/mL of the compound triggered ERK2/AKT phosphorylation, NO production, and the upregulation of IL-6 and MIP-3α [1].
In vivo
In studies using Zebrafish (Danio rerio), ODN 2007 demonstrates protective effects against bacterial infection. Administration of the compound increases the survival rate of zebrafish challenged with Vibrio vulnificus [2].
SynonymsODN-2007, ODN2007
Chemical Properties
Molecular Weight6852.5
Cas No.455348-63-7
SequenceDNA, d(P-thio)(T-C-G-T-C-G-T-T-G-T-C-G-T-T-T-T-G-T-C-G-T-T)
Storage & Solubility Information
StorageIn solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 16 mg/mL (2.33 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM0.1459 mL0.7297 mL1.4593 mL7.2966 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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