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Siltuximab
(Synonyms: CNTO-328) Copy Product Info
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Synonyms: CNTO-328
Catalog No. T76978 Copy Product Info
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Siltuximab(CNTO-328) is a monoclonal antibody with anti-tumor activity targeting IL-6 for the study of giant lymph node hyperplasia (MCD) and COVID-19.
Cas No. 541502-14-1
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $178 | In Stock | In Stock | |
| 5 mg | $439 | In Stock | In Stock | |
| 10 mg | $648 | - | In Stock | |
| 25 mg | $987 | - | In Stock | |
| 50 mg | $1,390 | - | In Stock | |
| 100 mg | $1,870 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:100% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
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Chemical Properties
Antibody Information
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| Description | Siltuximab(CNTO-328) is a monoclonal antibody with anti-tumor activity targeting IL-6 for the study of giant lymph node hyperplasia (MCD) and COVID-19. |
| In vivo | In xenograft mouse models, Siltuximab, when administered through intraperitoneal injection at a dosage of 10 mg/kg three times per week, inhibits the growth of lung cancer cells[1]. Furthermore, in a xenograft model, the growth of MCF-7 tumors is inhibited by Siltuximab with intraperitoneal injections at a dose of 20 mg/kg twice per week for 6 weeks[3]. |
| Expression System | CHO |
| Endotoxin | <1 EU/mg |
| Synonyms | CNTO-328 |
| Reactivity | Human |
| Verified Activity | Immobilized Human IL-6 Protein (His) at 2 μg/mL (30 μL/well) can bind Siltuximab. The EC50 is 58.73 ng/mL. |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | IL-6/IFNb2 |
| Molecular Weight | 144.98 kDa |
| Cas No. | 541502-14-1 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Siltuximab chemical structure | Siltuximab in vivo | Siltuximab molecular weight
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