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MMAF sodium

Name: MMAF sodium
Brand: TargetMol
SKU: T16122
Rating: 4.5 (1 reviews)

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Catalog No. T16122Cas No. 1799706-65-2

Alias Monomethylauristatin F sodium

MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF sodium is an effective tubulin polymerization inhibitor and is used as an antitumor agent.

MMAF sodium

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Catalog No. T16122Alias Monomethylauristatin F sodiumCas No. 1799706-65-2

Pack Size	Price	Availability
25 mg	$5,180	10-14 weeks
50 mg	$9,010	10-14 weeks
100 mg	$9,830	10-14 weeks

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Product Introduction

Bioactivity

Description	MMAF sodium is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. MMAF sodium is an effective tubulin polymerization inhibitor and is used as an antitumor agent.
In vitro	MMAF suppresses anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O, and Caki-1 cells. It has IC50s of 119, 105, 257, and 200 nM in vitro cytotoxicity assay[4].
Synonyms	Monomethylauristatin F sodium

Chemical Properties

Molecular Weight	753.94
Formula	C₃₉H₆₄N₅NaO₈
Cas No.	1799706-65-2
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (265.27 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3264 mL	6.6318 mL	13.2637 mL	66.3183 mL
5 mM	0.2653 mL	1.3264 mL	2.6527 mL	13.2637 mL
10 mM	0.1326 mL	0.6632 mL	1.3264 mL	6.6318 mL
20 mM	0.0663 mL	0.3316 mL	0.6632 mL	3.3159 mL
50 mM	0.0265 mL	0.1326 mL	0.2653 mL	1.3264 mL
100 mM	0.0133 mL	0.0663 mL	0.1326 mL	0.6632 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc