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MTEP hydrochloride

Name: MTEP hydrochloride
Brand: TargetMol
SKU: T7515
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7515Cas No. 1186195-60-7

Alias MTEP HCL

MTEP hydrochloride (MTEP) is non-competitive mGlu5 antagonist (IC50 and Ki of 5 nM and 16 nM, respectively)

MTEP hydrochloride

🥰Excellent

Purity: 99.58%

Catalog No. T7515Alias MTEP HCLCas No. 1186195-60-7

MTEP hydrochloride (MTEP) is non-competitive mGlu5 antagonist (IC50 and Ki of 5 nM and 16 nM, respectively)

Pack Size	Price	Availability
2 mg	$35	In Stock
5 mg	$57	In Stock
10 mg	$90	In Stock
25 mg	$198	In Stock
50 mg	$395	In Stock
100 mg	$593	In Stock
200 mg	$822	In Stock

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Batch Information

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Purity:99.58%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	MTEP hydrochloride (MTEP) is non-competitive mGlu5 antagonist (IC50 and Ki of 5 nM and 16 nM, respectively)
Targets&IC50	mGlu5:16 nM(ki), mGlu5:5 nM
In vivo	Male Albino Swiss mice were used, and antidepressant-like activity was evaluated using the FST.?The antidepressant-like effect of MTEP (0.3 mg/kg) was significantly antagonized by pre-treatment with the NMDA receptor agonist N-methyl-D-aspartic acid (NMDA, 75 mg/kg)[1].
Synonyms	MTEP HCL

Chemical Properties

Molecular Weight	236.72
Formula	C₁₁H₉ClN₂S
Cas No.	1186195-60-7
Smiles	Cl.Cc1nc(cs1)C#Cc1cccnc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 20 mg/mL (84.49 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	4.2244 mL	21.1220 mL	42.2440 mL	211.2200 mL
5 mM	0.8449 mL	4.2244 mL	8.4488 mL	42.2440 mL
10 mM	0.4224 mL	2.1122 mL	4.2244 mL	21.1220 mL
20 mM	0.2112 mL	1.0561 mL	2.1122 mL	10.5610 mL
50 mM	0.0845 mL	0.4224 mL	0.8449 mL	4.2244 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc