ω-Hydroxy-DEET

Name: ω-Hydroxy-DEET
Brand: TargetMol
SKU: T40833
Rating: 4.5 (1 reviews)

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Catalog No. T40833Cas No. 72236-22-7

ω-Hydroxy-DEET, a significant metabolite of the insect repellent N-N-diethyl-meta-toluamide (DEET), exhibits anti-proliferative properties. DEET, renowned for being a spatial repellent and irritant, is frequently employed to deter mosquito contact.

ω-Hydroxy-DEET

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Catalog No. T40833Cas No. 72236-22-7

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Product Introduction

Bioactivity

Description	ω-Hydroxy-DEET, a significant metabolite of the insect repellent N-N-diethyl-meta-toluamide (DEET), exhibits anti-proliferative properties. DEET, renowned for being a spatial repellent and irritant, is frequently employed to deter mosquito contact.
In vitro	Studies on hepatoma cells demonstrate that treatment with ω-Hydroxy-DEET (DHMB; at concentrations ranging from 0.1 to 10 μg/mL for durations of 48 to 72 hours) leads to decreased cellular proliferation [1].
In vivo	Following both intravenous and topical administration of DEET in rats, the metabolite ω-Hydroxy-DEET (DHMB) showed extensive distribution, with ω-Hydroxy-DEET emerging as DEET's principal metabolite. Notably, repeated daily topical applications over a 30-day period resulted in elevated ω-Hydroxy-DEET concentrations in the liver[1].

Chemical Properties

Molecular Weight	207.27
Formula	C₁₂H₁₇NO₂
Cas No.	72236-22-7
Smiles	CCN(CC)C(=O)c1cccc(CO)c1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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