ω-Hydroxy-DEET

Name: ω-Hydroxy-DEET
Brand: TargetMol
SKU: T40833
Rating: 4.5 (1 reviews)

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Catalog No. T40833Cas No. 72236-22-7

ω-Hydroxy-DEET, a significant metabolite of the insect repellent N-N-diethyl-meta-toluamide (DEET), exhibits anti-proliferative properties. DEET, renowned for being a spatial repellent and irritant, is frequently employed to deter mosquito contact.

ω-Hydroxy-DEET

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Catalog No. T40833Cas No. 72236-22-7

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Product Introduction

Bioactivity

Description	ω-Hydroxy-DEET, a significant metabolite of the insect repellent N-N-diethyl-meta-toluamide (DEET), exhibits anti-proliferative properties. DEET, renowned for being a spatial repellent and irritant, is frequently employed to deter mosquito contact.
In vitro	Studies on hepatoma cells demonstrate that treatment with ω-Hydroxy-DEET (DHMB; at concentrations ranging from 0.1 to 10 μg/mL for durations of 48 to 72 hours) leads to decreased cellular proliferation [1].
In vivo	Following both intravenous and topical administration of DEET in rats, the metabolite ω-Hydroxy-DEET (DHMB) showed extensive distribution, with ω-Hydroxy-DEET emerging as DEET's principal metabolite. Notably, repeated daily topical applications over a 30-day period resulted in elevated ω-Hydroxy-DEET concentrations in the liver[1].

Chemical Properties

Molecular Weight	207.27
Formula	C₁₂H₁₇NO₂
Cas No.	72236-22-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

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